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Isolation and characterization of novel bacteriophage, vB_AbaA_SWMUZ8, targeting multidrug-resistant Acinetobacter baumannii strains
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Isolation and characterization of novel bacteriophage, vB_AbaA_SWMUZ8, targeting multidrug-resistant Acinetobacter baumannii strains
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Isolation and characterization of novel bacteriophage, vB_AbaA_SWMUZ8, targeting multidrug-resistant Acinetobacter baumannii strains
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Journal Article
Isolation and characterization of novel bacteriophage, vB_AbaA_SWMUZ8, targeting multidrug-resistant Acinetobacter baumannii strains
2026
Overview
Background
Acinetobacter baumannii
is a significant opportunistic pathogen causing severe nosocomial infections that poses increasing clinical challenges due to escalating multidrug resistance. Phage therapy has emerged as a promising alternative strategy to combat multidrug-resistant (MDR) infections.
Results
In this study, a lytic phage targeting ST208/KL2-type
A. baumannii
strain Ac28 was isolated and purified from hospital sewage. Whole-genome sequencing and a bioinformatics analysis successfully identified a novel podovirus, designated “vB_AbaA_SWMUZ8”. A host-range analysis demonstrated a lysis rate of 58.33% against 84 clinically derived
A. baumannii
isolates of diverse multilocus sequence types, with particularly high efficacy against 88% of ST208 strains. Notably, vB_AbaA_SWMUZ8 lysed 100% of geographically co-localized isolates. It inhibited the growth of MDR
A. baumannii
strain Ac28 in vitro and improve survival rates in a
Galleria mellonella
infection model.
Conclusions
In this work, we identified a therapeutically promising lytic phage and provided evidence for the phage-based control of MDR
A. baumannii
infections.
Publisher
BioMed Central,Springer Nature B.V
Subject
/ Acinetobacter baumannii - drug effects
/ Acinetobacter baumannii - genetics
/ Acinetobacter baumannii - isolation & purification
/ Acinetobacter baumannii - virology
/ Acinetobacter Infections - microbiology
/ Acinetobacter Infections - therapy
/ Animals
/ Bacteria
/ Bacteriophages - classification
/ Bacteriophages - isolation & purification
/ Biomedical and Life Sciences
/ Drug Resistance, Multiple, Bacterial
/ Humans
/ Mycology
/ Phages
/ Podoviridae - classification
/ Podoviridae - isolation & purification
/ Sewage
/ Transmission electron microscopy
/ Virology
