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Influence of the Breast Tumor Stromal Fibroblasts on Immunological Processes In Vitro
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Influence of the Breast Tumor Stromal Fibroblasts on Immunological Processes In Vitro
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Journal Article
Influence of the Breast Tumor Stromal Fibroblasts on Immunological Processes In Vitro
2025
Overview
The effects of stromal cell cultures isolated from breast cancer tissue on the differentiation and maturation of dendritic cells and proliferation of lymphocytes were studied
in vitro
. The derived cultures had the fibroblast-like morphology and carried mesenchymal markers CD73 and CD90 in the absence of epithelial (CD326, CD24) and macrophage (CD68) markers. The cells also expressed CD44, CD10, and CD29 and had low levels of HLA-ABC expression. Intracellular expression of fibroblast activation protein (FAP), tenascin C, and α-SMA indicated their activated state and stromal origin. Analysis of the functional properties of the cells revealed their ability to suppress differentiation of dendritic cells from monocytes, as well as the proliferation of T lymphocytes. However, they had no significant effect on DC maturation. The results demonstrate that fibroblasts in the tumor stroma of breast cancer may have a suppressive effect on important mechanisms of the adaptive immunity and can be involved in the process of tumor escape from the immunological control.
Publisher
Springer US,Springer Nature B.V
Subject
/ 5'-Nucleotidase - immunology
/ 5'-Nucleotidase - metabolism
/ Biomedical and Life Sciences
/ Breast Neoplasms - immunology
/ Breast Neoplasms - pathology
/ Cancer-Associated Fibroblasts - immunology
/ Dendritic Cells - immunology
/ Dendritic Cells - metabolism
/ Female
/ Fibroblast activation protein
/ GPI-Linked Proteins - genetics
/ GPI-Linked Proteins - immunology
/ GPI-Linked Proteins - metabolism
/ Humans
/ Hyaluronan Receptors - genetics
/ Hyaluronan Receptors - immunology
/ Hyaluronan Receptors - metabolism
/ Membrane Proteins - genetics
/ Membrane Proteins - immunology
/ Membrane Proteins - metabolism
/ Serine Endopeptidases - genetics
/ Serine Endopeptidases - immunology
/ Serine Endopeptidases - metabolism
/ Tenascin
/ Tumors
