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Oligodendrocytes Up-regulate the Invasive Activity of Glioblastoma Cells via the Angiopoietin-2 Signaling Pathway

by OHATA, KENJI , KAWASHIMA, TOSHIYUKI , KASASHIMA, HIROAKI , TERAKAWA, YUZO , TANOUE, YUTA , NAKAJO, KOSUKE , UMABA, RYOKO , YASHIRO, MASAKAZU , UDA, TAKEHIRO , TAMRAKAR, SAMANTHA

in Angiopoietin / Angiopoietin-2 - metabolism / Antibodies / Antibodies, Neutralizing - chemistry / Brain cancer / Brain Neoplasms - metabolism / Brain Neoplasms - pathology / Cell Line, Tumor / Cell lines / Cell Movement / Cell Proliferation / Cells / Culture Media, Conditioned / Cytokines / Enzymes / Fibroblasts / Fibroblasts - metabolism / Gene Expression Regulation, Neoplastic / Glioblastoma / Glioblastoma - metabolism / Glioblastoma - pathology / Glioblastoma cells / Glioma / Glioma - metabolism / Glioma cells / Humans / Invasiveness / Medical prognosis / Morphology / Neoplasm Invasiveness / Oligodendrocytes / Oligodendroglia - cytology / Proteome / Signal Transduction / Stromal cells / Stromal Cells - metabolism / Up-Regulation / Wound healing

2019

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Oligodendrocytes Up-regulate the Invasive Activity of Glioblastoma Cells via the Angiopoietin-2 Signaling Pathway

by OHATA, KENJI , KAWASHIMA, TOSHIYUKI , KASASHIMA, HIROAKI , TERAKAWA, YUZO , TANOUE, YUTA , NAKAJO, KOSUKE , UMABA, RYOKO , YASHIRO, MASAKAZU , UDA, TAKEHIRO , TAMRAKAR, SAMANTHA

2019

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Oligodendrocytes Up-regulate the Invasive Activity of Glioblastoma Cells via the Angiopoietin-2 Signaling Pathway

by OHATA, KENJI , KAWASHIMA, TOSHIYUKI , KASASHIMA, HIROAKI , TERAKAWA, YUZO , TANOUE, YUTA , NAKAJO, KOSUKE , UMABA, RYOKO , YASHIRO, MASAKAZU , UDA, TAKEHIRO , TAMRAKAR, SAMANTHA

2019

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Journal Article

Oligodendrocytes Up-regulate the Invasive Activity of Glioblastoma Cells via the Angiopoietin-2 Signaling Pathway

OHATA, KENJI,

KAWASHIMA, TOSHIYUKI,

KASASHIMA, HIROAKI,

TERAKAWA, YUZO,

TANOUE, YUTA,

NAKAJO, KOSUKE,

UMABA, RYOKO,

YASHIRO, MASAKAZU,

UDA, TAKEHIRO,

TAMRAKAR, SAMANTHA

2019

Overview

Glioblastoma (GBM) is one of the most lethal solid cancers due to its highly invasive nature. The malignant potential of GBM cells might be partially regulated by surrounding normal cells, such as oligodendrocytes or fibroblasts. The aim of this study was to examine the interaction between stromal cells and GBM cells. Two GBM cell lines were used. The effect of stromal cells, oligodendrocytes or fibroblasts, on the invasive ability of GBM cells was examined by wound-healing assay and invasion assay. Oligodendrocytes, in contrast to fibroblasts, significantly increased the migration and invasive ability of GBM cells. Angiopoietin-2 levels were high in the conditioned medium obtained from oligodendrocytes. Angiopoietin-2 significantly increased the motility of GBM, and the motility-stimulating activity of the oligodendrocytes-derived conditioned medium was significantly decreased by anti-angiopoietin-2-neutralizing antibody. Glioma stromal cells, oligodendrocytes, might up-regulate the invasiveness of GBM cells via angiopoietin-2 signaling.

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Publisher

International Institute of Anticancer Research

Subject

Angiopoietin

/ Angiopoietin-2 - metabolism

/ Antibodies

/ Antibodies, Neutralizing - chemistry

/ Brain cancer

/ Brain Neoplasms - metabolism

/ Brain Neoplasms - pathology