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Editorial: The pathogenesis and treatment of Helicobacter pylori-induced diseases
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Editorial: The pathogenesis and treatment of Helicobacter pylori-induced diseases
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Journal Article
Editorial: The pathogenesis and treatment of Helicobacter pylori-induced diseases
2023
Overview
Empirical triple (proton pump inhibitor + two antibiotics) and quadruple therapy (proton pump inhibitor + bismuth + two antibiotics), and even novel high-dose dual therapy (proton pump inhibitor + high dose amoxicillin), have been used to clear H. pylori in the clinic, but the increasing rate of drug resistance is bringing great challenges to effective bactericidal treatment worldwide (O’Connor et al., 2017; Liou et al., 2023). Gene mutation, efflux pump, coccoid and biofilm formation, and intracellular survival contribute to the known mechanisms of the bacteria against antibiotics (Kuo et al., 2017; Tshibangu-Kabamba and Yamaoka, 2021). [...]H. pylori re-isolated from curcumin-fed mice in a phospholipid formulation appeared to be less virulent. The results showed that SPEM cell lineage differentiation, interaction with H. pylori, disturbances of the mucosal microenvironment, biomarkers, clinical diagnosis, and the outcomes of SPEM, as well as the development of proliferative SPEM animal models, were the major focus of research.
Publisher
Frontiers Media SA,Frontiers Media S.A
