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Adenosine is required for sustained inflammasome activation via the A2A receptor and the HIF-1α pathway
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Adenosine is required for sustained inflammasome activation via the A2A receptor and the HIF-1α pathway
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Journal Article
Adenosine is required for sustained inflammasome activation via the A2A receptor and the HIF-1α pathway
2013
Overview
Inflammasome pathways are important in chronic diseases; however, it is not known how the signalling is sustained after initiation. Inflammasome activation is dependent on stimuli such as lipopolysaccharide (LPS) and ATP that provide two distinct signals resulting in rapid production of interleukin (IL)-1β, with the lack of response to repeat stimulation. Here we report that adenosine is a key regulator of inflammasome activity, increasing the duration of the inflammatory response via the A
2A
receptor. Adenosine does not replace signals provided by stimuli such as LPS or ATP but sustains inflammasome activity via a cAMP/PKA/CREB/HIF-1α pathway. In the setting of the lack of IL-1β responses after previous exposure to LPS, adenosine can supersede this tolerogenic state and drive IL-1β production. These data reveal that inflammasome activity is sustained, after initial activation, by A
2A
receptor-mediated signalling.
Inflammasome activation can lead to chronic inflammatory conditions; however, the mechanisms controlling the duration of this activation are not well understood. Here, Ouyang
et al.
report that adenosine sustains inflammasome activity, which brings insights into the pathology of chronic inflammatory diseases.
Publisher
Nature Publishing Group UK
Subject
/ 13/106
/ Adenosine Triphosphate - metabolism
/ Animals
/ Carrier Proteins - metabolism
/ Cyclic AMP Response Element-Binding Protein - genetics
/ Cyclic AMP Response Element-Binding Protein - metabolism
/ Cyclic AMP-Dependent Protein Kinases - metabolism
/ Humanities and Social Sciences
/ Hypoxia-Inducible Factor 1, alpha Subunit - metabolism
/ Inflammasomes - drug effects
/ Interleukin-1beta - metabolism
/ Lipopolysaccharides - metabolism
/ Lipopolysaccharides - pharmacology
/ Male
/ Mice
/ NLR Family, Pyrin Domain-Containing 3 Protein
/ Receptor, Adenosine A2A - genetics
/ Receptor, Adenosine A2A - metabolism
/ Science
