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Leukotriene B4 receptor BLT1 mediates early effector T cell recruitment
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Leukotriene B4 receptor BLT1 mediates early effector T cell recruitment
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Journal Article
Leukotriene B4 receptor BLT1 mediates early effector T cell recruitment
2003
Overview
Leukotriene B
4
(LTB
4
) was originally described as a potent lipid myeloid cell chemoattractant, rapidly generated from innate immune cells, that activates leukocytes through the G protein–coupled receptor BLT1. We report here that BLT1 is expressed on effector CD4
+
T cells generated
in vitro
as well as
in vivo
when effector T cells migrate out of the lymphoid compartment and are recruited into peripheral tissues. BLT1 mediated LTB
4
-induced T helper type 1 (T
H
1) and T
H
2 cell chemotaxis and firm adhesion to endothelial cells under flow, as well as early CD4
+
and CD8
+
T cell recruitment into the airway in an asthma model. Our findings show that the LTB
4
-BLT1 pathway is involved in linking early immune system activation and early effector T cell recruitment.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ Animals
/ Asthma
/ Biomedical and Life Sciences
/ Bronchoalveolar Lavage Fluid - cytology
/ CD4-Positive T-Lymphocytes - immunology
/ Chemotaxis, Leukocyte - immunology
/ Female
/ Immunoglobulin E - immunology
/ Immunoglobulin G - immunology
/ Lymphocyte Activation - immunology
/ Male
/ Mice
