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Splenic marginal zone lymphoma with prolymphocytic transformation and cyclin D1 expression in the absence of CCND1 rearrangement
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Splenic marginal zone lymphoma with prolymphocytic transformation and cyclin D1 expression in the absence of CCND1 rearrangement
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Journal Article
Splenic marginal zone lymphoma with prolymphocytic transformation and cyclin D1 expression in the absence of CCND1 rearrangement
2024
Overview
Splenic marginal zone lymphoma (SMZL) is one of the most common B-cell lymphomas that affect the spleen. We report a case with splenomegaly and lymphocytosis that showed a clonal B-cell population lacking CD5 and CD10 expression. Notably, the atypical lymphoid cells showed prolymphocytoid morphology and expressed cyclin D1. Fluorescence in-situ hybridization was negative for CCND1/IgH rearrangement. The prolymphocytoid morphology and cyclin D1 expression present a diagnostic pitfall. The clinical presentation, morphology, immunophenotype, and molecular genetic findings are most consistent with a diagnosis of SMZL with prolymphocytic transformation and cyclin D1 expression. Here, we present this case along with a review of the literature, and summarize the clinicopathological characteristics of SMZL with prolymphocytic transformation.
Publisher
Springer Nature Singapore,Springer Nature B.V
Subject
/ Biopsy
/ Cells
/ Disease
/ Humans
/ In Situ Hybridization, Fluorescence
/ Leukemia
/ Lymphoma
/ Lymphoma, B-Cell, Marginal Zone - diagnosis
/ Lymphoma, B-Cell, Marginal Zone - genetics
/ Lymphoma, B-Cell, Marginal Zone - pathology
/ Medicine
/ Mutation
/ Oncology
/ Patients
/ Spleen
/ Splenic Neoplasms - diagnosis
/ Splenic Neoplasms - genetics
/ Splenic Neoplasms - metabolism
