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Retinal vessel density and choroidal flow changes in oligoarticular juvenile idiopathic arthritis with and without uveitis
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Retinal vessel density and choroidal flow changes in oligoarticular juvenile idiopathic arthritis with and without uveitis
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Journal Article
Retinal vessel density and choroidal flow changes in oligoarticular juvenile idiopathic arthritis with and without uveitis
2024
Overview
Purpose
This cross-sectional optical coherence tomography angiography (OCTA) study aimed to assess the macular and optic nerve head (ONH) vascular density, foveal avascular zone, and outer retina and choriocapillaris flow in oligoarticular juvenile idiopathic arthritis (oJIA).
Study design
Prospective.
Methods
Twenty-two eyes of 22 oJIA patients with uveitis (oJIA-U), 20 eyes of 20 oJIA patients without uveitis (isolated oJIA), and 26 healthy volunteers of similar ages and sexes were investigated. The superficial capillary plexus (SCP) and deep capillary plexus (DCP), ONH, foveal avascular zone (FAZ) parameters, the flow area of the outer retina, and choriocapillaris were evaluated.
Results
Compared with the control group, both the oJIA-U group and isolated oJIA group showed significantly decreased vessel density of parafovea (
p
= 0.031 and
p
= 0.047, respectively) in DCP. Choriocapillaris flow area at 1 mm radius was significantly lower in the oJIA-U group compared to the control group (
p
= 0.001). Choriocapillaris flow area at 2- and 3-mm radius were significantly lower in the oJIA-U group compared to the control group (
p
< 0.001, for both) and isolated oJIA-U group compared to the control group (
p
= 0.008 and
p
= 0.001, respectively). The VD and thickness parameters of SCP and ONH, FAZ, and outer retina flow area were similar between the groups.
Conclusions
oJIA patients with and without uveitis revealed a decreased vessel density in the deep parafoveal region and choriocapillaris flow. Our findings suggest that retinal choroidal microvascular changes could be evident in oJIA-U patients without posterior segment involvement as well as oJIA patients without uveitis.
Publisher
Springer Japan,Springer Nature B.V
Subject
/ Adult
/ Arthritis, Juvenile - complications
/ Arthritis, Juvenile - physiopathology
/ Child
/ Choroid - diagnostic imaging
/ Density
/ Female
/ Fluorescein Angiography - methods
/ Humans
/ Male
/ Medicine
/ Optics
/ Regional Blood Flow - physiology
/ Retina
/ Retinal Vessels - diagnostic imaging
/ Retinal Vessels - physiopathology
/ Tomography, Optical Coherence - methods
/ Uveitis
