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Xalnesiran with or without an Immunomodulator in Chronic Hepatitis B
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Xalnesiran with or without an Immunomodulator in Chronic Hepatitis B
Xalnesiran with or without an Immunomodulator in Chronic Hepatitis B
Journal Article

Xalnesiran with or without an Immunomodulator in Chronic Hepatitis B

2024
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Overview
In a phase 2 trial involving participants taking a nucleoside or nucleotide analogue, 23% of those assigned to receive xalnesiran plus pegylated interferon alfa-2a had HBsAg loss at 24 weeks after the end of treatment.
Publisher
Massachusetts Medical Society
Subject

Adult

/ Adverse events

/ Alanine transaminase

/ Antigens

/ Antiviral Agents - administration & dosage

/ Antiviral Agents - adverse effects

/ Chronic infection

/ Clinical significance

/ Drug dosages

/ Drug Therapy, Combination - adverse effects

/ Drug Therapy, Combination - methods

/ Female

/ Gastroenterology

/ Gastroenterology General

/ Genetics

/ Genetics General

/ Global Health

/ Hepatitis B

/ Hepatitis B surface antigen

/ Hepatitis B Surface Antigens - blood

/ Hepatitis B virus - drug effects

/ Hepatitis B virus - genetics

/ Hepatitis B virus - immunology

/ Hepatitis B, Chronic - blood

/ Hepatitis B, Chronic - drug therapy

/ Hepatitis B, Chronic - immunology

/ Humans

/ Immunomodulating Agents - administration & dosage

/ Immunomodulating Agents - adverse effects

/ Immunomodulation

/ Immunomodulators

/ Infections

/ Infectious Disease

/ Infectious Disease General

/ Interferon-alpha - administration & dosage

/ Interferon-alpha - adverse effects

/ Liver cancer

/ Liver cirrhosis

/ Liver Disease

/ Male

/ Middle Aged

/ Nucleoside analogs

/ Nucleosides - administration & dosage

/ Nucleosides - adverse effects

/ Nucleosides - analogs & derivatives

/ Nucleotide analogs

/ Polyethylene Glycols - adverse effects

/ Polyethylene Glycols - therapeutic use

/ Recombinant Proteins - administration & dosage

/ Recombinant Proteins - adverse effects

/ RNA Therapeutics

/ RNA viruses

/ RNA, Small Interfering - administration & dosage

/ RNA, Small Interfering - adverse effects

/ Seroconversion

/ siRNA

/ Treatment Outcome

/ Viral Infections

/ α-Interferon