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Direct potentiometry and potentiotitrimetry of warfarin and ibuprofen in pharmaceutical preparations using PVC ferroin-based membrane sensors
by
Abdel-Samad, Mohamed S.
, Mahmoud, Wagiha H.
, Hassan, Saad S. M.
in
Analysis
/ Anions
/ Biological and medical sciences
/ Dioctylphthalate
/ Drag
/ Dynamic response
/ Electrical measurement
/ Electroactive materials
/ General pharmacology
/ Ibuprofen
/ Ion association
/ Medical sciences
/ Membranes
/ Nonsteroidal anti-inflammatory drugs
/ Pharmaceuticals
/ Pharmacology. Drug treatments
/ Potentiometric analysis
/ Sensors
/ Silver chloride
/ Titration
/ Warfarin
1998
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Direct potentiometry and potentiotitrimetry of warfarin and ibuprofen in pharmaceutical preparations using PVC ferroin-based membrane sensors
by
Abdel-Samad, Mohamed S.
, Mahmoud, Wagiha H.
, Hassan, Saad S. M.
in
Analysis
/ Anions
/ Biological and medical sciences
/ Dioctylphthalate
/ Drag
/ Dynamic response
/ Electrical measurement
/ Electroactive materials
/ General pharmacology
/ Ibuprofen
/ Ion association
/ Medical sciences
/ Membranes
/ Nonsteroidal anti-inflammatory drugs
/ Pharmaceuticals
/ Pharmacology. Drug treatments
/ Potentiometric analysis
/ Sensors
/ Silver chloride
/ Titration
/ Warfarin
1998
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Direct potentiometry and potentiotitrimetry of warfarin and ibuprofen in pharmaceutical preparations using PVC ferroin-based membrane sensors
by
Abdel-Samad, Mohamed S.
, Mahmoud, Wagiha H.
, Hassan, Saad S. M.
in
Analysis
/ Anions
/ Biological and medical sciences
/ Dioctylphthalate
/ Drag
/ Dynamic response
/ Electrical measurement
/ Electroactive materials
/ General pharmacology
/ Ibuprofen
/ Ion association
/ Medical sciences
/ Membranes
/ Nonsteroidal anti-inflammatory drugs
/ Pharmaceuticals
/ Pharmacology. Drug treatments
/ Potentiometric analysis
/ Sensors
/ Silver chloride
/ Titration
/ Warfarin
1998
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Direct potentiometry and potentiotitrimetry of warfarin and ibuprofen in pharmaceutical preparations using PVC ferroin-based membrane sensors
Journal Article
Direct potentiometry and potentiotitrimetry of warfarin and ibuprofen in pharmaceutical preparations using PVC ferroin-based membrane sensors
1998
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Overview
Sensitive and fast-responding potentiometric sensors are described for the determination of warfarin and ibuprofen. They consist of PVC matrix membranes containing the drag-ferroin ion-association complexes as electroactive materials and dioctylphthalate as a solvent mediator. Linear dynamic response range between 1 × 10−2 and 2 × 10−5M with Nernstian slopes of 59–60 mV/decade concentration and a detection limit of 0.8–1.3 μg/ml are obtained. A wide range of organic anions and drag excipients do not interfere. Titration of the drugs with a standard ferroin solution using either a drag-ferroin or ferroin-TPB PVC sensor in conjunction with an Ag-AgCl reference electrode displaysS-shaped titration curves with sharp potential breaks at stoichiometric 1∶2 (ferroin:drug) reaction. Differential titration curves with well-defined peaks at the equivalence points are obtained using drug-ferroin/ferroin-TPB PVC membrane sensors. Direct potentiometry and potentiotitrimetry of warfarin and ibuprofen in various pharmaceutical preparations are presented and compared. Several advantages over the pharmacopoeial methods and other techniques in current use are offered by the proposed technique.
Publisher
Springer,Springer Nature B.V
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