Asset Details
Do you wish to reserve the book?
Expansion of highly stable bla OXA-10 β-lactamase family within diverse host range among nosocomial isolates of Gram-negative bacilli within a tertiary referral hospital of Northeast India
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Expansion of highly stable bla OXA-10 β-lactamase family within diverse host range among nosocomial isolates of Gram-negative bacilli within a tertiary referral hospital of Northeast India
Do you wish to request the book?
Expansion of highly stable bla OXA-10 β-lactamase family within diverse host range among nosocomial isolates of Gram-negative bacilli within a tertiary referral hospital of Northeast India
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Expansion of highly stable bla OXA-10 β-lactamase family within diverse host range among nosocomial isolates of Gram-negative bacilli within a tertiary referral hospital of Northeast India
2017
Overview
The current study reports dissemination of highly stable bla
family of beta lactamases among diverse group of nosocomial isolates of Gram-negative bacilli within a tertiary referral hospital of the northern part of India.
In the current study, a total number of 590 Gram negative isolates were selected for a period of 1 year (i.e. 1st November 2011-31st October 2012). Members of Enterobacteriaceae and non fermenting Gram negative rods were obtained from Silchar Medical College and Hospital, Silchar, India. Screening and molecular characterization of β-lactamase genes was done. Integrase gene PCR was performed for detection and characterization of integrons and cassette PCR was performed for study of the variable regions of integron gene cassettes carrying bla
. Gene transferability, stability and replicon typing was also carried out. Isolates were typed by ERIC as well as REP PCR.
Twenty-four isolates of Gram-negative bacilli that were harboring bla
family (OXA-14, and OXA16) with fact that resistance was to the extended cephalosporins. The resistance determinant was located within class I integron in five diverse genetic contexts and horizontally transferable in Enterobacteriaceae, was carried through IncY type plasmid. MIC values were above break point for all the tested cephalosporins. Furthermore, co-carriage of bla
was also observed.
Multiple genetic environment of bla
in this geographical region must be investigated to prevent dissemination of these gene cassettes within bacterial population within hospital settings.
Publisher
Springer Nature B.V,BMC
Subject
Anti-Bacterial Agents - pharmacology
/ Bacilli
/ Cephalosporins - pharmacology
/ Cross Infection - microbiology
/ Drug Resistance, Bacterial - genetics
/ E coli
/ Enterobacteriaceae - classification
/ Enterobacteriaceae - drug effects
/ Enterobacteriaceae - enzymology
/ Enterobacteriaceae Infections - microbiology
/ Expanded-spectrum cephalosporins
/ Feces
/ Female
/ Genes
/ Humans
/ IncY
/ India
/ Integron
/ Male
/ Medicine
/ Methods
/ Plasmids
/ Surgery
/ Urine
