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Plasma proteomic analysis of active and torpid greater mouse-eared bats (Myotis myotis)
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Plasma proteomic analysis of active and torpid greater mouse-eared bats (Myotis myotis)
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Journal Article
Plasma proteomic analysis of active and torpid greater mouse-eared bats (Myotis myotis)
2015
Overview
Hibernation is a physiological adaptation to overcome extreme environmental conditions. It is characterized by prolonged periods of torpor interrupted by temporary arousals during winter. During torpor, body functions are suppressed and restored rapidly to almost pre-hibernation levels during arousal. Although molecular studies have been performed on hibernating rodents and bears, it is unclear how generalizable the results are among hibernating species with different physiology such as bats. As targeted blood proteomic analysis are lacking in small hibernators, we investigated the general plasma proteomic profile of European
Myotis myotis
and hibernation associated changes between torpid and active individuals by two-dimensional gel electrophoresis. Results revealed an alternation of proteins involved in transport, fuel switching, innate immunity and blood coagulation between the two physiological states. The results suggest that metabolic changes during hibernation are associated with plasma proteomic changes. Further characterization of the proteomic plasma profile identified transport proteins, coagulation proteins and complement factors and detected a high abundance of alpha-fetoprotein. We were able to establish for the first time a basic myotid bat plasma proteomic profile and further demonstrated a modulated protein expression during torpor in
Myotis myotis
, indicating both novel physiological pathways in bats in general and during hibernation in particular.
