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A Multicenter Randomized Prospective Study of Early Cholecystectomy for Pediatric Patients with Biliary Colic
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A Multicenter Randomized Prospective Study of Early Cholecystectomy for Pediatric Patients with Biliary Colic
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A Multicenter Randomized Prospective Study of Early Cholecystectomy for Pediatric Patients with Biliary Colic
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Journal Article
A Multicenter Randomized Prospective Study of Early Cholecystectomy for Pediatric Patients with Biliary Colic
2021
Overview
Background
In patients with biliary colic, high-quality prospective data supporting the precise timing of cholecystectomy are lacking. The purpose of this study was to determine the effectiveness of early laparoscopic cholecystectomy in children with biliary colic.
Methods
A multicenter, parallel-group, randomized study was conducted in patients with biliary colic at 5 hospitals in China. Pediatric patients with biliary colic were prospectively randomized to either the early cholecystectomy or conservative management strategy. The clinical outcomes within 6 months, including the number of biliary colic-free patients and gallstone-related complications, were compared (register number ChiCTR1900021830).
Results
During the first 2 months of follow-up, 71 patients (59.2%, 71/120) receiving conservative management and 124 patients (97.6%, 124/127) in the early cholecystectomy group (
p
< 0.001) reported being entirely colic-free. The GIQLI measures were higher in the early cholecystectomy group than in the conservative management group (
p
= 0.032). Acute readmissions occurred in 7 (5.5%) of 127 patients in the early cholecystectomy group, compared with 23 (19.2%) of 120 patients in the conservative management group (risk ratio [RR] 0.25; 95% CI [0.10–0.60],
p
= 0.001) in the 6-month period.
Conclusions
Early cholecystectomy is effective in providing beneficial outcomes in terms of both short-term and long-term improvement of symptoms.
