Asset Details
Do you wish to reserve the book?
Association between Apo B, LDL-R and PCSK9 gene polymorphisms with coronary artery diseases in Egyptians
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Association between Apo B, LDL-R and PCSK9 gene polymorphisms with coronary artery diseases in Egyptians
Do you wish to request the book?
Association between Apo B, LDL-R and PCSK9 gene polymorphisms with coronary artery diseases in Egyptians
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Association between Apo B, LDL-R and PCSK9 gene polymorphisms with coronary artery diseases in Egyptians
2024
Overview
Background
Many studies have focused on the significance of lipid regulatory genes in the pathophysiology of Coronary artery disease (CAD). ApoB XbaI (rs693) and EcoRI (rs1042031) single nucleoid polymorphisms (SNPs) were investigated to detect whether they are risk factors for CAD. Till now, this association remains uncertain. SMARCA4 (rs1122608) SNP has directly related to dyslipidemia. Loss of function mutations (LOF) in PCSK9 result in a reduction in LDL cholesterol and are associated with protection from the development of CAD.
Methods
This study was conducted on 54 CAD patients who were admitted at Internal Medicine Specialized Hospital (Cardiology Department) and 47 healthy controls. Peripheral blood samples were taken from both groups. DNA was extracted from EDTA-blood samples, then PCR- RFLP for ApoB XbaI (rs693) and EcoRI (rs1042031), SMARCA4 (rs1122608) and PCSK9 (rs505151) SNPs was done.
Results
No statistically significant difference was found between patients and controls as regard EcoRI SNP. XbaI (rs693) X + X + genotype was significantly higher in control group (
P
= 0.0355). SMARCA4 (TT, GT + TT) genotypes, and T allele (
P
< 0.001); PCSK9 AG genotype and G allele (
P
= 0.027 and 0.032 respectively) were more frequent in CAD patients than controls.
Conclusion
SMARCA4 (rs1122608) and PCSK9 (rs505151) SNPs are significantly accompanying with the risk of CAD development in the Egyptian population. X + X + genotype appeared to have a protective effect against CAD. However, no observed association between EcoRI (rs1042031) and the risk of CAD development was found.
Publisher
Springer Netherlands,Springer Nature B.V
Subject
/ Aged
/ Alleles
/ Apolipoproteins B - genetics
/ Biomedical and Life Sciences
/ blood
/ Coronary Artery Disease - genetics
/ Deoxyribonuclease EcoRI - genetics
/ DNA
/ Female
/ Genetic Predisposition to Disease
/ Genotype
/ Humans
/ low density lipoprotein cholesterol
/ Male
/ medicine
/ Polymorphism, Single Nucleotide - genetics
/ Proprotein Convertase 9 - genetics
/ risk
