Journal Article

Gene × Environment effects of serotonin transporter, dopamine receptor D4, and monoamine oxidase A genes with contextual and parenting risk factors on symptoms of oppositional defiant disorder, anxiety, and depression in a community sample of 4-year-old children

Cook, Edwin H., Hopkins, Joyce, Gouze, Karen R., Herzing, Laura B. K., Lavigne, John V., Lebailly, Susan A., Bryant, Fred B.

2013

Overview

Genetic factors can play a key role in the multiple level of analyses approach to understanding the development of child psychopathology. The present study examined gene–environment correlations and Gene × Environment interactions for polymorphisms of three target genes, the serotonin transporter gene, the D4 dopamine receptor gene, and the monoamine oxidase A gene in relation to symptoms of anxiety, depression, and oppositional behavior. Saliva samples were collected from 175 non-Hispanic White, 4-year-old children. Psychosocial risk factors included socioeconomic status, life stress, caretaker depression, parental support, hostility, and scaffolding skills. In comparison with the short forms (s/s, s/l) of the serotonin transporter linked polymorphic repeat, the long form (l/l) was associated with greater increases in symptoms of oppositional defiant disorder in interaction with family stress and with greater increases in symptoms of child depression and anxiety in interaction with caretaker depression, family conflict, and socioeconomic status. In boys, low-activity monoamine oxidase A gene was associated with increases in child anxiety and depression in interaction with caretaker depression, hostility, family conflict, and family stress. The results highlight the important of gene–environment interplay in the development of symptoms of child psychopathology in young children.

• Publisher: Cambridge University Press
• Subject: Anxiety / Anxiety - diagnosis / Anxiety - genetics / Anxiety - psychology / Attention Deficit and Disruptive Behavior Disorders - diagnosis / Attention Deficit and Disruptive Behavior Disorders - genetics / Attention Deficit and Disruptive Behavior Disorders - psychology / Boys / Caregiver burden / Caretakers / Child development / Child psychology / Child, Preschool / Children / Depression - diagnosis / Depression - genetics / Depression - psychology / Dopamine / Environment / Families & family life / Family conflict / Family relations / Family support / Female / Gene-Environment Interaction / Genes / Genetics / Genotype / Hostility / Humans / Life stress / Male / Mental depression / Mental Disorders / Monoamine Oxidase - genetics / Neurons / Oppositional defiant disorder / Parent-Child Relations / Parenting - psychology / Parents & parenting / Psychopathology / Psychosocial factors / Receptors, Dopamine D4 - genetics / Regular Articles / Risk Factors / Saliva / Serotonin / Serotonin Plasma Membrane Transport Proteins - genetics / Serotonin receptors / Short forms / Socioeconomic factors / Socioeconomic status / Stress / Symptom Assessment / Symptoms