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Two sodium channels contribute to the TTX-R sodium current in primary sensory neurons
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Two sodium channels contribute to the TTX-R sodium current in primary sensory neurons
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Two sodium channels contribute to the TTX-R sodium current in primary sensory neurons
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Journal Article
Two sodium channels contribute to the TTX-R sodium current in primary sensory neurons
1998
Overview
We have cloned a second tetrodotoxin-resistant (TTX-R) sodium channel α subunit, SNS2, with the same amino-acid sequence as a putative sodium channel α subunit NaN (ref.
1
). SNS2 expression in HEK293T cells produced a TTX-R voltage-gated sodium current with faster kinetics and a lower TTX IC
50
than the previously cloned sensory-neuron-specific sodium channel, SNS/PN3 (Refs
2
,
3
). SNS2 was co-expressed with SNS/PN3 in small DRG neurons.
Publisher
Nature Publishing Group US
