Journal Article

Evaluation of simultaneous multi-slice acquisition with advanced processing for free-breathing diffusion-weighted imaging in patients with liver metastasis

Castagnoli, Francesca, d’Arcy, James, Orton, Matthew R., Winfield, Jessica M., Stemmer, Alto, Nickel, Marcel Dominik, Rata, Mihaela, De Paepe, Katja N., Koh, Dow-Mu, Hughes, Julie

2024

Overview

Objectives Diffusion-weighted imaging (DWI) with simultaneous multi-slice (SMS) acquisition and advanced processing can accelerate acquisition time and improve MR image quality. This study evaluated the image quality and apparent diffusion coefficient (ADC) measurements of free-breathing DWI acquired from patients with liver metastases using a prototype SMS-DWI acquisition (with/without an advanced processing option) and conventional DWI. Methods Four DWI schemes were compared in a pilot 5-patient cohort; three DWI schemes were further assessed in a 24-patient cohort. Two readers scored image quality of all b -value images and ADC maps across the three methods. ADC measurements were performed, for all three methods, in left and right liver parenchyma, spleen, and liver metastases. The Friedman non-parametric test (post-hoc Wilcoxon test with Bonferroni correction) was used to compare image quality scoring; t -test was used for ADC comparisons. Results SMS-DWI was faster (by 24%) than conventional DWI. Both readers scored the SMS-DWI with advanced processing as having the best image quality for highest b -value images (b750) and ADC maps; Cohen’s kappa inter-reader agreement was 0.6 for b750 image and 0.56 for ADC maps. The prototype SMS-DWI sequence with advanced processing allowed a better visualization of the left lobe of the liver. ADC measured in liver parenchyma, spleen, and liver metastases using the SMS-DWI with advanced processing option showed lower values than those derived from the SMS-DWI method alone ( t -test, p  < 0.0001; p  < 0.0001; p  = 0.002). Conclusions Free-breathing SMS-DWI with advanced processing was faster and demonstrated better image quality versus a conventional DWI protocol in liver patients. Clinical relevance statement Free-breathing simultaneous multi-slice- diffusion-weighted imaging (DWI) with advanced processing was faster and demonstrated better image quality versus a conventional DWI protocol in liver patients. Key Points • Diffusion-weighted imaging (DWI) with simultaneous multi-slice (SMS) can accelerate acquisition time and improve image quality. • Apparent diffusion coefficients (ADC) measured in liver parenchyma, spleen, and liver metastases using the simultaneous multi-slice DWI with advanced processing were significantly lower than those derived from the simultaneous multi-slice DWI method alone. • Simultaneous multi-slice DWI sequence with inline advanced processing was faster and demonstrated better image quality in liver patients.

• Publisher: Springer Berlin Heidelberg,Springer Nature B.V
• Subject: Diagnostic Radiology / Diffusion coefficient / Diffusion Magnetic Resonance Imaging - methods / Diffusion rate / Echo-Planar Imaging - methods / Evaluation / Humans / Image acquisition / Image quality / Imaging / Internal Medicine / Interventional Radiology / Liver / Liver Neoplasms - diagnostic imaging / Magnetic Resonance / Medicine / Medicine & Public Health / Metastases / Metastasis / Neuroradiology / Parenchyma / Patients / Prototypes / Radiology / Reproducibility of Results / Respiration / Spleen / Ultrasound