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Medical treatment of gastroesophageal reflux in the neonatal intensive care unit: current practice
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Medical treatment of gastroesophageal reflux in the neonatal intensive care unit: current practice
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Journal Article
Medical treatment of gastroesophageal reflux in the neonatal intensive care unit: current practice
2025
Overview
Objective
To determine current prescribing practice of acid-suppressive therapy in preterm infants admitted to the neonatal intensive care unit (NICU).
Study design
Cohort study of infants 22 to 27 weeks gestation discharged from Pediatrix Medical Group NICUs between 2015 and 2020.
Results
Of 13,735 infants meeting inclusion criteria, 11% were exposed to acid-suppressive therapy during hospitalization, with 3% of those treated on the day of discharge. Exposed infants had lower birthweights (BW) (
p
< 0.001). 42% of infants exposed to acid-suppressive therapy received a gastroesophageal reflux disease (GERD) diagnosis (
p
< 0.001). Median (25th–75th percentile) duration of use was 7 (4–14) days. Use decreased overall during the 5-year period (
p
< 0.001).
Conclusion
Acid-suppressive therapies are used commonly in preterm infants and receipt is higher in infants with lower BWs. Use has significantly decreased over time and appears to be targeted, with many infants treated for one-week courses and without a diagnosis of GERD.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ Acids
/ Exposure
/ Female
/ Gastroesophageal Reflux - diagnosis
/ Gastroesophageal Reflux - drug therapy
/ Humans
/ Infant, Premature, Diseases - drug therapy
/ Infants
/ Intensive Care Units, Neonatal
/ Male
/ Medicine
/ Neonates
/ Practice Patterns, Physicians' - statistics & numerical data
/ Proton Pump Inhibitors - therapeutic use
/ Therapy
