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Multimodal Vacuum-Assisted Plasma Ion (VaPI) Source with Transmission Mode and Laser Ablation Sampling Capabilities

by Farnsworth, Paul B. , Abbott-Lyon, Heather , Keelor, Joel D. , L. Weber, Arthur , Fernández, Facundo M.

in Analytical Chemistry / Bioinformatics / Biotechnology / Chemistry / Chemistry and Materials Science / Flow velocity / Gas temperature / Helium / Ionization / Laser ablation / Lasers / Mass spectrometry / Organic Chemistry / Proteomics / Research Article / Sampling / Tablets

2016

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Multimodal Vacuum-Assisted Plasma Ion (VaPI) Source with Transmission Mode and Laser Ablation Sampling Capabilities

by Farnsworth, Paul B. , Abbott-Lyon, Heather , Keelor, Joel D. , L. Weber, Arthur , Fernández, Facundo M.

2016

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Multimodal Vacuum-Assisted Plasma Ion (VaPI) Source with Transmission Mode and Laser Ablation Sampling Capabilities

by Farnsworth, Paul B. , Abbott-Lyon, Heather , Keelor, Joel D. , L. Weber, Arthur , Fernández, Facundo M.

2016

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Journal Article

Multimodal Vacuum-Assisted Plasma Ion (VaPI) Source with Transmission Mode and Laser Ablation Sampling Capabilities

Farnsworth, Paul B.,

Abbott-Lyon, Heather,

Keelor, Joel D.,

L. Weber, Arthur,

Fernández, Facundo M.

2016

Overview

We have developed a multimodal ion source design that can be configured on the fly for various analysis modes, designed for more efficient and reproducible sampling at the mass spectrometer atmospheric pressure (AP) interface in a number of different applications. This vacuum-assisted plasma ionization (VaPI) source features interchangeable transmission mode and laser ablation sampling geometries. Operating in both AC and DC power regimes with similar results, the ion source was optimized for parameters including helium flow rate and gas temperature using transmission mode to analyze volatile standards and drug tablets. Using laser ablation, matrix effects were studied, and the source was used to monitor the products of model prebiotic synthetic reactions. Graphical Abstract ᅟ

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Publisher

Springer US,Springer Nature B.V

Subject

/ Chemistry and Materials Science

/ Flow velocity

/ Gas temperature