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Basal and FSH-stimulated Inhibin B in Precocious Puberty
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Journal Article
Basal and FSH-stimulated Inhibin B in Precocious Puberty
2024
Overview
Objective
To evaluate the role of basal and follicle-stimulating hormone (FSH)-stimulated inhibin B in differentiating premature thelarche from gonadotropin-dependent precocious puberty (GDPP).
Method
This was a prospective interventional study. Basal and FSH-stimulated inhibin B levels were estimated in girls presenting with thelarche < 8 years age (
n
= 10), healthy girls with normal pubertal development (pubertal control) (
n
= 8) and healthy prepubertal girls (prepubertal control) (
n
= 7). Girls with early puberty were classified as premature thelarche or GDPP based on GnRH agonist stimulation test.
Results
Median (IQR) basal inhibin B levels (pg/mL) in premature thelarche was 5.42 (2.91, 30.58) and FSH-stimulated inhibin B was 236.72 (111.53, 4431.73) (
P
= 0.043). Median (IQR) basal inhibin B in GDPP was 64.11 (24.96, 792.45) pg/mL and FSH-stimulated inhibin B was 833.66 (500.11–1266.18) pg/mL (
P
= 0.043). Basal inhibin B was discriminatory between GDPP and premature thelarche (
P
= 0.032). Median (IQR) basal inhibin B in prepubertal and pubertal controls was 20.36 (9.61, 29.12) and 75.48 (58.55, 165.55) pg/mL, respectively.
Conclusion
Basal inhibin B is useful in differentiation of premature thelarche from GDPP while the role of FSH-stimulated inhibin B needs to be further explored in large sample size.
Publisher
Springer India,Nature Publishing Group
Subject
