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Clinicopathological Significance of Autophagy-related Proteins and its Association With Genetic Alterations in Gliomas
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Clinicopathological Significance of Autophagy-related Proteins and its Association With Genetic Alterations in Gliomas
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Journal Article
Clinicopathological Significance of Autophagy-related Proteins and its Association With Genetic Alterations in Gliomas
2019
Overview
To investigate clinicopathological significance of autophagy and its association with genetic alterations in gliomas.
The expression of three autophagy-related proteins, light chain-3 (LC3), beclin 1, and p62 was immunohistochemically analyzed in 32 low-grade gliomas and 65 high-grade gliomas.
LC3, beclin 1, and p62 expression was positive in 70/94 (74%), 51/94 (54%) and 55/96 (57%) gliomas, respectively. High expression of LC3, beclin 1 and p62 was significantly more frequent in high-grade gliomas than in low-grade. Positive expression of LC3, beclin 1 and p62 were significantly positively correlated with overall survival, methylation of O
-methylyguanine-DNA methyltransferase (MGMT) promoter, mutations of isocitrate dehydrogenase 1 (IDH1) and telomerase reverse transcriptase (TERT) promoter, and 1p/19q co-deletion. Kaplan-Meier analyses revealed that LC3, p62 and autophagy status (positivity for at least two of the three proteins) were significantly associated with poorer survival.
Autophagy might be associated with the progression of glioma, particularly high-grade, and thus might be a useful prognostic factor in patients with glioma.
Publisher
International Institute of Anticancer Research
Subject
/ Adult
/ Aged
/ Brain Neoplasms - metabolism
/ Female
/ Glioma
/ Humans
/ Male
/ Microtubule-Associated Proteins - genetics
/ Microtubule-Associated Proteins - metabolism
/ Mutation
/ O6-methylguanine-DNA methyltransferase
/ Patients
/ Proteins
/ Sequestosome-1 Protein - genetics
/ Sequestosome-1 Protein - metabolism
/ Survival
/ Telomerase reverse transcriptase
/ Tumors
