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Increased Infiltration of Natural Killer and T Cells in Colorectal Liver Metastases Improves Patient Overall Survival
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Increased Infiltration of Natural Killer and T Cells in Colorectal Liver Metastases Improves Patient Overall Survival
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Journal Article
Increased Infiltration of Natural Killer and T Cells in Colorectal Liver Metastases Improves Patient Overall Survival
2017
Overview
Introduction
Cancer heterogeneity and degree of intra-tumoral immune cells represent variables affecting overall survival (OS). The present study investigated the impact of natural killer (NK) and T cells infiltrating colorectal liver metastases (CLM) in patients undergoing hepatectomy after neoadjuvant chemotherapy.
Methods
The frequencies of intra-tumoral, marginal, and peritumoral CD3+ T and NKp46+ NK cells were determined for 121 patients. OS was assessed in relation to prognostic factors.
Results
At univariate analysis, several variables, including T and N of the primary tumor, metachronous CLM, radiological response, and higher density of intra-tumoral CD3+ T cell (>1%/mm
2
) and of NKp46+ NK cells (>1 cell/mm
2
), were associated with OS. Only increased frequencies of intra-tumoral CD3+ T cells (
p
= 0.005) and NKp46+ NK cells (
p
= 0.004) correlated with OS at multivariate analysis. The logistic regression revealed that metachronous CLM (OR = 2.781;
p
= 0.002), the use of an epidermal growth factor receptor inhibitor (OR = 3.891;
p
= 0.001), and radiological response (OR = 3.219;
p
= 0.001) were associated with higher infiltration of these cells.
Conclusions
High frequencies of NK and T cells in response to chemotherapy predict OS in CLM patients. These findings provide important insights that can help physicians to choose the best treatment option and adopt more predictive follow-up strategies for patients with CLM.
Publisher
Springer US,Springer Nature B.V
Subject
2016 SSAT Plenary Presentation
/ Adult
/ Aged
/ Antineoplastic Agents - therapeutic use
/ Colorectal Neoplasms - mortality
/ Colorectal Neoplasms - pathology
/ ErbB Receptors - antagonists & inhibitors
/ Female
/ Humans
/ Liver Neoplasms - immunology
/ Lymphocytes, Tumor-Infiltrating
/ Male
/ Medicine
/ Surgery
