Asset Details
Do you wish to reserve the book?
Molecular evolution and spatial transmission of severe fever with thrombocytopenia syndrome virus
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Molecular evolution and spatial transmission of severe fever with thrombocytopenia syndrome virus
Do you wish to request the book?
Molecular evolution and spatial transmission of severe fever with thrombocytopenia syndrome virus
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Molecular evolution and spatial transmission of severe fever with thrombocytopenia syndrome virus
2026
Overview
Severe fever with thrombocytopenia syndrome virus (SFTSV), an emerging pathogen from the family
Phenuiviridae
, poses severe threats to public health in East Asia. In this study, we elucidate SFTSV’s epidemiological dynamics, transmission patterns, and molecular determinants of virulence, through analysis of 1942 genomes obtained from multiple host species across endemic regions in China, South Korea, Japan, and Thailand (2005–2023). Phylogenetic reconstruction delineates two major lineages (L1-Chinese and L2-Japanese-Korean) comprising 13 genotypes (I-XIII). Viral diversity is shaped by extensive segment-specific reassortment (212 events, including L1-L1, L2-L2, and L1-L2 patterns) and recombination (69 events, 62 in China). The M segment exhibited significantly elevated recombination frequency compared to the L and S segments. Geographically, Hubei province in China emerges as a reassortment hotspot with exceptional genotype diversity, while Henan, Hubei, and Zhejiang provinces serve as key recombination centers. Bayesian phylogeographic analysis traces the origin of SFTSV to the Jiangsu-Anhui border region (~17th century). Subsequent spread occurred through two distinct transmission networks: the L1 lineage disseminated terrestrially from Jiangsu-Anhui/Shandong to the Dabie Mountains and Liaoning province, while the L2 lineage dispersed via marine routes, with South Korea acting as a key transmission hub. Integration of clinical data identifies five positively selected sites and mortality-associated co-mutation networks that are enriched in the genotype IV, which is associated with mortality.
Authors reconstruct the molecular evolution of severe fever with thrombocytopenia syndrome virus (SFTSV) in East Asia. SFTSV splits into two lineages with diversity driven by segment-specific reassortment; transmission occurs via distinct networks.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 45/91
/ Animals
/ Fever
/ Genomes
/ Genotype
/ Humanities and Social Sciences
/ Humans
/ Multiple organ dysfunction syndrome
/ Networks
/ Phlebovirus - classification
/ Reassortant Viruses - genetics
/ Regions
/ Republic of Korea - epidemiology
/ Science
/ Segments
/ Severe Fever with Thrombocytopenia Syndrome - epidemiology
/ Severe Fever with Thrombocytopenia Syndrome - transmission
/ Severe Fever with Thrombocytopenia Syndrome - virology
/ Viruses
