Asset Details

MbrlCatalogueTitleDetail

Do you wish to reserve the book?

Differences in telomere length between patients with bipolar disorder and controls are influenced by lithium treatment

by Cocco, Cristina , Pinna, Federica , Sogos, Valeria , Ferri, Gian Luca , Noli, Barbara , Zompo, Maria Del , Nieddu, Mariella , Vanni, Roberta , Squassina, Alessio , Chillotti, Caterina , Dettori, Tinuccia , Pisanu, Claudia , Robledo, Renato , Frau, Daniela Virginia , Ardau, Raffaella , Manca, Elias , Meloni, Anna , Caria, Paola , Congiu, Donatella , Bocchetta, Alberto , Manchia, Mirko , Carpiniello, Bernardo , Severino, Giovanni

in Adult / aging / Antidepressive Agents - pharmacology / Antidepressive Agents - therapeutic use / Bipolar Disorder - diagnosis / Bipolar Disorder - drug therapy / Bipolar Disorder - genetics / Female / Genome-Wide Association Study - methods / Humans / Leukocytes - drug effects / Leukocytes - physiology / Lithium Compounds - pharmacology / Lithium Compounds - therapeutic use / Longitudinal Studies / Male / mendelian randomization mood disorders / Middle Aged / mood stabilizers / pharmacogenetics / Telomere - drug effects / Telomere - physiology / telomere shortening / Telomere Shortening - drug effects / Telomere Shortening - physiology / telomeres / Treatment Outcome

2020

Yes Please

Hey, we have placed the reservation for you!

By the way, why not check out events that you can attend while you pick your title.

Oops! Something went wrong.

Looks like we were not able to place the reservation. Kindly try again later.

Are you sure you want to remove the book from the shelf?

Differences in telomere length between patients with bipolar disorder and controls are influenced by lithium treatment

2020

Confirm

Do you wish to request the book?

Differences in telomere length between patients with bipolar disorder and controls are influenced by lithium treatment

2020

Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy

How would you like to get it?

Submit

We have requested the book for you!

Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.

Oops! Something went wrong.

Looks like we were not able to place your request. Kindly try again later.

Journal Article

Differences in telomere length between patients with bipolar disorder and controls are influenced by lithium treatment

Cocco, Cristina,

Pinna, Federica,

Sogos, Valeria,

Ferri, Gian Luca,

Noli, Barbara,

Zompo, Maria Del,

Nieddu, Mariella,

Vanni, Roberta,

Squassina, Alessio,

Chillotti, Caterina,

Dettori, Tinuccia,

Pisanu, Claudia,

Robledo, Renato,

Frau, Daniela Virginia,

Ardau, Raffaella,

Manca, Elias,

Meloni, Anna,

Caria, Paola,

Congiu, Donatella,

Bocchetta, Alberto,

Manchia, Mirko,

Carpiniello, Bernardo,

Severino, Giovanni

2020

Overview

To assess the role of lithium treatment in the relationship between bipolar disorder (BD) and leukocyte telomere length (LTL). We compared LTL between 131 patients with BD, with or without a history of lithium treatment, and 336 controls. We tested the association between genetically determined LTL and BD in two large genome-wide association datasets. Patients with BD with a history lithium treatment showed longer LTL compared with never-treated patients (p = 0.015), and similar LTL compared with controls. Patients never treated with lithium showed shorter LTL compared with controls (p = 0.029). Mendelian randomization analysis showed no association between BD and genetically determined LTL. Our data support previous findings showing that long-term lithium treatment might protect against telomere shortening.

Share this book

Add to My Shelf

Publisher

Future Medicine Ltd

Subject

Adult

/ aging

/ Antidepressive Agents - pharmacology

/ Antidepressive Agents - therapeutic use

/ Bipolar Disorder - diagnosis

/ Bipolar Disorder - drug therapy

/ Bipolar Disorder - genetics