Asset Details
Do you wish to reserve the book?
The effects of β-carotene on osteoporosis: a systematic review and meta-analysis of observational studies
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
The effects of β-carotene on osteoporosis: a systematic review and meta-analysis of observational studies
Do you wish to request the book?
The effects of β-carotene on osteoporosis: a systematic review and meta-analysis of observational studies
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
The effects of β-carotene on osteoporosis: a systematic review and meta-analysis of observational studies
2023
Overview
Purpose
The aim is to evaluate the effect of β-carotene for osteoporosis and provide quantitative evidence.
Method
PubMed, Embase, Web of Science, and Cochrane Library were searched for eligible studies. Fifteen studies were included. Random-effect model was applied to pool the odds ratio (OR). The risk of osteoporosis and fracture were compared between low β-carotene intake group and high β-carotene intake group.
Result
The intake of β-carotene was unassociated with the overall risk of osteoporosis [OR = 0.733, 95% Cl (0.528, 1.018),
p
= 0.064]. Subgroup analysis showed that the intake of β-carotene was negatively associated with the risk of osteoporosis in both male subgroup [OR = 0.7, 95% Cl (0.549, 0.893),
I
2
= 40.40%,
p
= 0.004] and female subgroup [OR = 0.684, 95% Cl (0.487, 0.960),
I
2
= 86.40%,
p
= 0.028]. There was also a negative association between β-carotene intake and osteoporosis in Asia subgroup [OR = 0.512, 95% Cl (0.403, 0.650),
I
2
= 0.00%,
p
= 0], whereas no association was observed in Western subgroup [OR = 1.107, 95% Cl (0.908, 1.350),
I
2
= 2.30%,
p
= 0.314]. In addition, random-effect model was adopted to pool the standard mean difference (SMD), and the results showed that β-carotene intake was positively associated with overall bone mineral density (BMD) [SMD = − 0.213, 95% Cl (− 0.391, − 0.034),
I
2
= 87.30%,
p
= 0.019]. Subgroup analysis showed that β-carotene intake was positively associated with BMD in Asian participants [SMD = − 0.394, 95% Cl (− 0.461, − 0.328),
I
2
= 0,
p
= 0], while unassociated in Western participants [SMD = − 0.047, 95% Cl (− 0.314, 0.219),
I
2
= 78.9%,
p
= 0.727].
Conclusion
β-carotene may improve BMD and reduce the risk of osteoporosis and fracture. However, these effects could vary by gender and race and need to be further validated by longitudinal studies.
Publisher
Springer London,Springer Nature B.V
Subject
