Journal Article

Palliative Surgery for Patients with Gastroesophageal Junction or Gastric Cancer: A Report on Clinical Observational Outcomes

Chen, Eunise, Badgwell, Brian D., Bruera, Eduardo, Song, Yun, Mansfield, Paul F., Ikoma, Naruhiko

2024

Overview

Background Few studies have focused on palliative surgery in patients with advanced gastroesophageal junction (GEJ) or gastric cancer. We sought to evaluate clinical observational outcomes following palliative surgery in this population. Patients and Methods Patients with GEJ or gastric cancer who underwent palliative surgery (1/2010–11/2022) were identified. The primary outcomes were symptom improvement, ability to tolerate an oral diet, discharge to home, 30 “good days” without hospitalization, and receipt of systemic treatment. Postoperative outcomes and survival were secondarily evaluated. Results Among 93 patients, the median age was 59 (IQR 47–68) years, and the median Eastern Cooperative Oncology Group Performance Status (ECOG-PS) was 1 (range 0–3). The most frequent indication for palliative surgery was primary tumor obstruction [75 (81%) patients]. The most common procedures were feeding tube placement in 60 (65%) and intestinal bypass in 15 (16%) patients. A total of 75 (81%) patients experienced symptom improvement. Of these, 19 (25%) developed recurrent and 49 (65%) developed new symptoms. ECOG-PS was significantly associated with symptom-free time. Among those who underwent a bypass, resection, or ostomy creation for malignant obstruction, 16 (80%) tolerated an oral diet. Postoperatively, 87 (94%) were discharged home, 72 (77%) had 30 good days, and 64 (69%) received systemic treatment. Postoperative complications occurred in 35 (38%) patients, and 7 (8%) died within 30 days. The median survival time was 7.7 (95% CI 6.4–10.40) months. Conclusions Patients with incurable GEJ or gastric cancer can benefit from palliative surgery. Prognosis and performance status should inform goals-of-care discussions and patient selection for surgical palliation.

• Publisher: Springer International Publishing,Springer Nature B.V
• Subject: Aged / Complications / Diet / Esophageal Neoplasms - mortality / Esophageal Neoplasms - pathology / Esophageal Neoplasms - surgery / Esophagogastric Junction - pathology / Esophagogastric Junction - surgery / Female / Follow-Up Studies / Gastrectomy - mortality / Gastric cancer / Gastrointestinal Oncology / Humans / Intestinal bypass / Male / Medical prognosis / Medicine / Medicine & Public Health / Middle Aged / Oncology / Palliation / Palliative Care - methods / Patients / Population studies / Postoperative / Postoperative Complications / Prognosis / Retrospective Studies / Stomach Neoplasms - pathology / Stomach Neoplasms - surgery / Surgery / Surgical Oncology / Survival / Survival Rate