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Matriptase-2/NR4A3 axis switches TGF-β action toward suppression of prostate cancer cell invasion, tumor growth, and metastasis
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Matriptase-2/NR4A3 axis switches TGF-β action toward suppression of prostate cancer cell invasion, tumor growth, and metastasis
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Journal Article
Matriptase-2/NR4A3 axis switches TGF-β action toward suppression of prostate cancer cell invasion, tumor growth, and metastasis
2022
Overview
Dysregulation of pericellular proteolysis is strongly implicated in cancer metastasis through alteration of cell invasion and the microenvironment. Matriptase-2 (MT-2) is a membrane-anchored serine protease which can suppress prostate cancer (PCa) cell invasion. In this study, we showed that MT-2 was down-regulated in PCa and could suppress PCa cell motility, tumor growth, and metastasis. Using microarray and biochemical analysis, we found that MT-2 shifted TGF-β action towards its tumor suppressor function by repressing epithelial-to-mesenchymal transition (EMT) and promoting Smad2 phosphorylation and nuclear accumulation to upregulate two TGF-β1 downstream effectors (p21 and PAI-1), culminating in hindrance of PCa cell motility and malignant growth. Mechanistically, MT-2 could dramatically up-regulate the expression of nuclear receptor NR4A3
via
iron metabolism in PCa cells. MT-2-induced NR4A3 further coactivated Smad2 to activate p21 and PAI-1 expression. In addition, NR4A3 functioned as a suppressor of PCa and mediated MT-2 signaling to inhibit PCa tumorigenesis and metastasis. These results together indicate that NR4A3 sustains MT-2 signaling to suppress PCa cell invasion, tumor growth, and metastasis, and serves as a contextual factor for the TGF-β/Smad2 signaling pathway in favor of tumor suppression
via
promoting p21 and PAI-1 expression.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 13/105
/ 13/51
/ 13/95
/ 38/109
/ 38/22
/ 38/39
/ 38/61
/ 38/77
/ 45/15
/ 45/29
/ 64/60
/ 82/80
/ Cyclin-dependent kinase inhibitor p21
/ DNA-Binding Proteins - metabolism
/ Epithelial-Mesenchymal Transition
/ Humans
/ Male
/ Medicine
/ Membrane Proteins - metabolism
/ Motility
/ Oncology
/ Plasminogen Activator Inhibitor 1
/ Prostatic Neoplasms - pathology
/ Receptors, Steroid - metabolism
/ Receptors, Thyroid Hormone - metabolism
/ Serine Endopeptidases - metabolism
/ Transforming Growth Factor beta1 - metabolism
/ Transforming growth factor-b
