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Emerging Benefits: Pathophysiological Functions and Target Drugs of the Sigma-1 Receptor in Neurodegenerative Diseases
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Emerging Benefits: Pathophysiological Functions and Target Drugs of the Sigma-1 Receptor in Neurodegenerative Diseases
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Journal Article
Emerging Benefits: Pathophysiological Functions and Target Drugs of the Sigma-1 Receptor in Neurodegenerative Diseases
2021
Overview
The sigma-1 receptor (Sig-1R) is encoded by the
SIGMAR1
gene and is a nonopioid transmembrane receptor located in the mitochondrial-associated endoplasmic reticulum membrane (MAM). It helps to locate endoplasmic reticulum calcium channels, regulates calcium homeostasis, and acts as a molecular chaperone to control cell fate and participate in signal transduction. It plays an important role in protecting neurons through a variety of signaling pathways and participates in the regulation of cognition and motor behavior closely related to neurodegenerative diseases. Based on its neuroprotective effects, Sig-1R has now become a breakthrough target for alleviating Alzheimer’s disease and other neurodegenerative diseases. This article reviews the most cutting-edge research on the function of Sig-1R under normal or pathologic conditions and target drugs of the sigma-1 receptor in neurodegenerative diseases.
Publisher
Springer US,Springer Nature B.V
Subject
/ Animals
/ Biomedical and Life Sciences
/ Depressive Disorder - drug therapy
/ Depressive Disorder - physiopathology
/ Drug Evaluation, Preclinical
/ Endoplasmic Reticulum - drug effects
/ Endoplasmic Reticulum - metabolism
/ Humans
/ Motor Activity - drug effects
/ Nerve Growth Factors - biosynthesis
/ Nerve Tissue Proteins - agonists
/ Nerve Tissue Proteins - physiology
/ Neurodegenerative Diseases - drug therapy
/ Neurodegenerative Diseases - physiopathology
/ Neuroprotective Agents - pharmacology
/ Neuroprotective Agents - therapeutic use
/ Rats
/ Receptors, sigma - physiology
/ Retinal Degeneration - drug therapy
/ Retinal Degeneration - physiopathology
/ Substance-Related Disorders - drug therapy
