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Assisted reproductive technology outcomes in women with congenital uterine anomalies: a systematic review
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Assisted reproductive technology outcomes in women with congenital uterine anomalies: a systematic review
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Assisted reproductive technology outcomes in women with congenital uterine anomalies: a systematic review
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Journal Article
Assisted reproductive technology outcomes in women with congenital uterine anomalies: a systematic review
2024
Overview
Purpose
The present systematic review aimed to assess the fecundity of women with congenital uterine anomalies (CUAs) undergoing assisted reproductive technology (ART).
Methods
The present systematic review of the literature was reported according to the PRISMA guidelines. We systematically searched PubMed, MEDLINE, Embase and Scopus, from database inception to 17th October 2023. Studies were deemed eligible only if they included women with CUAs clearly fitting into one of the categories of the ASRM Müllerian anomalies classification 2021.
Results
Data relevant to the reproductive outcomes of women with CUAs who underwent ART were extracted from 55 studies. Regarding Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome, studies on gestational surrogacy reported a live birth rate (LBR) ranging from 37 to 54%. Uterus transplant, although still experimental, showed promising results. Most studies reported a negative impact of unicornuate uterus and partial or complete septate uterus on both the miscarriage rate (MR) and the live birth rate (LBR). The reproductive prognosis of women with unicornuate uterus was shown to be particularly poor in case of twin pregnancy. Uterus didelphys, bicornuate and arcuate uterus seem not to negatively impact the ART reproductive outcomes. Uterus didelphys was associated with an increased risk of preterm birth (PTB), cesarean section and low birth weight (LBW).
Conclusion
Women with CUAs should be informed regarding the impact (if any) of their congenital anomaly on both the chances of success of ART and on pregnancy-related complications. Elective single embryo transfer (eSET) should always be the first choice in patients with an increased baseline obstetric risk.
Publisher
Springer Berlin Heidelberg,Springer Nature B.V
Subject
46, XX Disorders of Sex Development - complications
/ Abortion, Spontaneous - epidemiology
/ Female
/ Humans
/ Medicine
/ Mullerian Ducts - abnormalities
/ Obstetrics/Perinatology/Midwifery
/ Premature Birth - epidemiology
/ Reproductive Techniques, Assisted
/ Review
/ Urogenital Abnormalities - complications
/ Urogenital Abnormalities - epidemiology
/ Uterus
