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Identification of a new orthonairovirus associated with human febrile illness in China
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Identification of a new orthonairovirus associated with human febrile illness in China
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Identification of a new orthonairovirus associated with human febrile illness in China
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Journal Article
Identification of a new orthonairovirus associated with human febrile illness in China
2021
Overview
The genus
Orthonairovirus
, which is part of the family
Nairoviridae
, includes the important tick-transmitted pathogens Crimean–Congo hemorrhagic fever virus and Nairobi sheep disease virus, as well as many other poorly characterized viruses found in ticks, birds and mammals
1
,
2
. In this study, we identified a new orthonairovirus, Songling virus (SGLV), from patients who reported being bitten by ticks in Heilongjiang Province in northeastern China. SGLV shared similar genomic and morphological features with orthonairoviruses and phylogenetically formed a unique clade in
Tamdy orthonairovirus
of the
Nairoviridae
family. The isolated SGLV induced cytopathic effects in human hepatoma cells in vitro. SGLV infection was confirmed in 42 hospitalized patients analyzed between 2017 and 2018, with the main clinical manifestations being headache, fever, depression, fatigue and dizziness. More than two-thirds (69%) of patients generated virus-specific antibody responses in the acute phase. Taken together, these results suggest that this newly discovered orthonairovirus is associated with human febrile illness in China.
Songling virus is a newly discovered orthonairovirus found in the blood of patients hospitalized with febrile illness and having a history of tick bites.
Publisher
Nature Publishing Group US,Nature Publishing Group
