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SARS-CoV-2, CT-Values, and Infectivity—Conclusions to Be Drawn from Side Observations
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SARS-CoV-2, CT-Values, and Infectivity—Conclusions to Be Drawn from Side Observations
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Journal Article
SARS-CoV-2, CT-Values, and Infectivity—Conclusions to Be Drawn from Side Observations
2021
Overview
When they analyzed the outcome of an external quality assessment challenge, it turned out that quantitative results deviate in 7.7% of cases by more than ±4 cycles (up to 18 cycles) from the respective individual means, leading to the conclusion that standardization is needed, if patient management procedures should be based on SARS-CoV-2 (RT) PCR Ct-values. [...]a recent study from Switzerland demonstrated that a number of further environmental factors, such as air–liquid interface, contact and temperature difference, are further important factors for successful SARS-CoV-2 replication in cell culture, leading to the conclusion that we still cannot rely on Ct-values as a marker for infectiousness [18]. [...]Kujawski and coworkers were also able to isolate a culturable virus from samples with higher Ct-values (>30) [12], suggesting that theoretically even small amounts of infectious particles might be enough to initiate an infection in vivo as long as no reliable data on the necessary minimum infective dose exists. The use of RATs is increasingly popular and some countries have discussed the easing of pandemic-related restrictions or exemptions from hygiene measures based on negative test results, but it must be emphasized that there is no data supporting the conclusion that an individual with a negative rapid antigen test cannot be infectious.
