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Editorial: Metabolic reprogramming in cancer
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Editorial: Metabolic reprogramming in cancer
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Journal Article
Editorial: Metabolic reprogramming in cancer
2025
Overview
Specifically, cancer cells alter their metabolic pathways to fulfill the augmented energy and building block requirements while managing oxidative stress crucial for their proliferation and survival (Nong et al., 2023). The flux through these metabolic pathways, underlying of cancer metabolic plasticity, is controlled by cancer driver mutations and environmental nutrient availability. [...]it is increasingly recognized that the metabolism of non-cancerous cell types within the TME, such as endothelial cells, fibroblasts, and immune cells, can influence tumor progression (Xia et al., 2021). Additionally, lipid droplets serve as alternative energy reservoirs, protecting CSCs from oxidative stress. [...]Ping et al.in their original article using a retrospective analysis described the predictive value of altered plasma omega-3 polyunsaturated fatty acids (omega-3 PUFAs) levels for early treatment response, progression free survival, and overall survival in patients with cervical squamous cell carcinoma (CSCC) who underwent concurrent chemoradiotherapy (CCRT).
