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Linkage analysis for ATM in familial B cell chronic lymphocytic leukaemia

by Gaminara, EJ , Houlston, RS , van Dongen, J , Catovsky, D , Popat, S , Mauro, FR , Yuille, MR , Antonovic, P , Marossy, A , Berrebi, A , Ribeiro, I , Sykes, H , Stark, P , Bell, A , Wright, S , Wimperis, J , Bevan, S , Matutes, E , Quabeck, K

in Adult / Aged / Aged, 80 and over / Ataxia / Ataxia telangiectasia / Ataxia Telangiectasia - genetics / Ataxia telangiectasia mutated protein / Ataxia Telangiectasia Mutated Proteins / Biological and medical sciences / Cell Cycle Proteins / Chromosome 11 / Chromosomes, Human, Pair 11 / Chronic lymphocytic leukemia / DNA-Binding Proteins / Female / Genetic Linkage / Germ-Line Mutation / Haplotypes / Hematologic and hematopoietic diseases / Heterozygote / Humans / Leukemia / Leukemia, Lymphocytic, Chronic, B-Cell - epidemiology / Leukemia, Lymphocytic, Chronic, B-Cell - genetics / Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis / Linkage analysis / Male / Medical sciences / Middle Aged / Mutation / Prevalence / Protein-Serine-Threonine Kinases / Proteins - genetics / Tumor Suppressor Proteins

1999

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Linkage analysis for ATM in familial B cell chronic lymphocytic leukaemia

1999

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Linkage analysis for ATM in familial B cell chronic lymphocytic leukaemia

1999

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Journal Article

Linkage analysis for ATM in familial B cell chronic lymphocytic leukaemia

Gaminara, EJ,

Houlston, RS,

van Dongen, J,

Catovsky, D,

Popat, S,

Mauro, FR,

Yuille, MR,

Antonovic, P,

Marossy, A,

Berrebi, A,

Ribeiro, I,

Sykes, H,

Stark, P,

Bell, A,

Wright, S,

Wimperis, J,

Bevan, S,

Matutes, E,

Quabeck, K

1999

Overview

B cell chronic lymphocytic leukaemia (CLL) shows evidence of familial aggregation, but the inherited basis is poorly understood. Mutations in the ATM gene have been demonstrated in CLL. This, coupled with a possibly increased risk of leukaemia in relatives of patients with Ataxia Telangiectasia, led us to question whether the ATM gene is involved in familial cases of CLL. To examine this proposition we typed five markers on chromosome 11q in 24 CLL families. No evidence for linkage between CLL and ATM in the 24 families studied and the best estimates of the proportion of sibling pairs that share no, one or both haplotypes at ATM were not different from their null expectations. This would imply that ATM is unlikely to make a significant contribution to the three-fold increase in risk of CLL seen in relatives of patients.

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Publisher

Nature Publishing,Nature Publishing Group

Subject

Adult

/ Aged

/ Aged, 80 and over

/ Ataxia

/ Ataxia telangiectasia

/ Ataxia Telangiectasia - genetics

/ Ataxia telangiectasia mutated protein