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Response to Y. Sasaki et al.: Is repeating FOLFIRINOX in the original dosage and treatment schedule tolerable in Japanese patients with pancreatic cancer?
Response to Y. Sasaki et al.: Is repeating FOLFIRINOX in the original dosage and treatment schedule tolerable in Japanese patients with pancreatic cancer?
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Response to Y. Sasaki et al.: Is repeating FOLFIRINOX in the original dosage and treatment schedule tolerable in Japanese patients with pancreatic cancer?
Response to Y. Sasaki et al.: Is repeating FOLFIRINOX in the original dosage and treatment schedule tolerable in Japanese patients with pancreatic cancer?

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Response to Y. Sasaki et al.: Is repeating FOLFIRINOX in the original dosage and treatment schedule tolerable in Japanese patients with pancreatic cancer?
Response to Y. Sasaki et al.: Is repeating FOLFIRINOX in the original dosage and treatment schedule tolerable in Japanese patients with pancreatic cancer?
Journal Article

Response to Y. Sasaki et al.: Is repeating FOLFIRINOX in the original dosage and treatment schedule tolerable in Japanese patients with pancreatic cancer?

2015
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Overview
[...]to introduce the FOLFIRINOX therapy as early as possible in Japan, we used the same dosing regimen as that in the ACCORD11 study. When we planned this trial, we already knew the results of the ACCORD11 study. [...]we considered that it would be more appropriate to assess the safety of the FOLFIRINOX regimen on a large cohort of Japanese patients rather than to assess dose limiting toxicity in 3–6 patients with an escalation of the patient doses by conducting a typical phase I study. [...]the response rate that was the primary endpoint was comparable to that of the ACCORD11 study.