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Dupilumab for Eosinophilic Esophagitis in Patients 1 to 11 Years of Age

by Samuely, Carin , Liu, Ruiqi , Wipperman, Matthew F. , Maloney, Jennifer , Collins, Margaret H. , Glotfelty, Lila , Yancopoulos, George D. , Laws, Elizabeth , Kamal, Mohamed A. , Lim, Wei Keat , Martincova, Renata , Rothenberg, Marc E. , Pesek, Robert D. , Mortensen, Eric , McCann, Eilish , Patel, Naimish , Kosloski, Matthew P. , Spergel, Jonathan M. , Hirano, Ikuo , Hamilton, Jennifer D. , Shabbir, Arsalan , Farrell, Annamaria , Dellon, Evan S. , Chehade, Mirna

in Adolescent Medicine / Age / Allergy / Antibodies, Monoclonal, Humanized - adverse effects / Antibodies, Monoclonal, Humanized - therapeutic use / Atopy / Biopsy / Body weight / Caregivers / Child / Child, Preschool / Clinical medicine / Coronaviruses / COVID-19 / Cytokines / Disease / Dose-Response Relationship, Drug / Double-Blind Method / Eosinophilic Esophagitis - drug therapy / Eosinophilic Esophagitis - immunology / Eosinophilic Esophagitis - pathology / Eosinophils - immunology / Eosinophils - pathology / Esophagitis / Esophagus / Esophagus - drug effects / Esophagus - immunology / Esophagus - pathology / Failure to thrive / Female / Gastroenterology / Gastroenterology General / Humans / Immunology / Immunology General / Infant / Inflammation / Inflammatory Disease / Injections, Subcutaneous / Interleukin 13 / Interleukin 4 / Interleukin-13 - antagonists & inhibitors / Interleukin-4 - antagonists & inhibitors / Leukocytes (eosinophilic) / Male / Monoclonal antibodies / Patient safety / Pediatrics / Pediatrics General / Placebos / Proton Pump Inhibitors - therapeutic use / Quality of life / Remission / Remission Induction / T-Cells / Teenagers / Transcriptomics / Treatment Outcome

2024

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Dupilumab for Eosinophilic Esophagitis in Patients 1 to 11 Years of Age

2024

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Dupilumab for Eosinophilic Esophagitis in Patients 1 to 11 Years of Age

2024

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Journal Article

Dupilumab for Eosinophilic Esophagitis in Patients 1 to 11 Years of Age

Samuely, Carin,

Liu, Ruiqi,

Wipperman, Matthew F.,

Maloney, Jennifer,

Collins, Margaret H.,

Glotfelty, Lila,

Yancopoulos, George D.,

Laws, Elizabeth,

Kamal, Mohamed A.,

Lim, Wei Keat,

Martincova, Renata,

Rothenberg, Marc E.,

Pesek, Robert D.,

Mortensen, Eric,

McCann, Eilish,

Patel, Naimish,

Kosloski, Matthew P.,

Spergel, Jonathan M.,

Hirano, Ikuo,

Hamilton, Jennifer D.,

Shabbir, Arsalan,

Farrell, Annamaria,

Dellon, Evan S.,

Chehade, Mirna

2024

Overview

Dupilumab, a human monoclonal antibody that blocks interleukin-4 and interleukin-13 pathways, led to histologic remission in a significantly higher percentage of children with eosinophilic esophagitis than placebo.

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Publisher

Massachusetts Medical Society

Subject

Adolescent Medicine

/ Age

/ Allergy

/ Antibodies, Monoclonal, Humanized - adverse effects

/ Antibodies, Monoclonal, Humanized - therapeutic use

/ Atopy

/ Biopsy