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Stem Cell–Derived, Fully Differentiated Islets for Type 1 Diabetes
by
Markmann, James F.
, Witkowski, Piotr
, Kandeel, Fouad
, Kean, Leslie S.
, Peters, Anne L.
, Reichman, Trevor W.
, Rickels, Michael R.
, Marigowda, Gautham
, de Koning, Eelco J.P.
, Wang, Chenkun
, Ricordi, Camillo
, Bruinsma, Bote G.
, Pagliuca, Felicia
, Mathieu, Chantal
, Mascia, Molly
, Odorico, Jon
, Fung, John J.
, Wijkstrom, Martin
, Sanna, Bastiano
, Melton, Doug
in
Adult
/ Blood Glucose - analysis
/ C-Peptide - blood
/ Cell Differentiation
/ Cell therapy
/ Childhood Diseases
/ Cognition
/ Dementia disorders
/ Diabetes
/ Diabetes mellitus (insulin dependent)
/ Diabetes Mellitus, Type 1 - blood
/ Diabetes Mellitus, Type 1 - diagnosis
/ Diabetes Mellitus, Type 1 - drug therapy
/ Diabetes Mellitus, Type 1 - surgery
/ Endocrinology
/ Endocrinology General
/ Female
/ Follow-Up Studies
/ Genetics
/ Genetics General
/ Glucagon
/ Glucose
/ Glycated Hemoglobin - analysis
/ Hemoglobin
/ Humans
/ Hypoglycemia
/ Hypoglycemia - blood
/ Hypoglycemia - diagnosis
/ Hypoglycemia - etiology
/ Hypoglycemic Agents - therapeutic use
/ Immunosuppressive agents
/ Immunosuppressive Agents - administration & dosage
/ Infusions, Intravenous
/ Insulin
/ Insulin - therapeutic use
/ Islets of Langerhans - cytology
/ Islets of Langerhans Transplantation - adverse effects
/ Islets of Langerhans Transplantation - methods
/ Male
/ Meningitis
/ Middle Aged
/ Neutropenia
/ Pediatrics
/ Pediatrics General
/ Peptides
/ Portal vein
/ Recovery of function
/ Statistical analysis
/ Stem Cells
/ Transplantation, Homologous
/ Transplants & implants
/ Young Adult
2025
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Stem Cell–Derived, Fully Differentiated Islets for Type 1 Diabetes
by
Markmann, James F.
, Witkowski, Piotr
, Kandeel, Fouad
, Kean, Leslie S.
, Peters, Anne L.
, Reichman, Trevor W.
, Rickels, Michael R.
, Marigowda, Gautham
, de Koning, Eelco J.P.
, Wang, Chenkun
, Ricordi, Camillo
, Bruinsma, Bote G.
, Pagliuca, Felicia
, Mathieu, Chantal
, Mascia, Molly
, Odorico, Jon
, Fung, John J.
, Wijkstrom, Martin
, Sanna, Bastiano
, Melton, Doug
in
Adult
/ Blood Glucose - analysis
/ C-Peptide - blood
/ Cell Differentiation
/ Cell therapy
/ Childhood Diseases
/ Cognition
/ Dementia disorders
/ Diabetes
/ Diabetes mellitus (insulin dependent)
/ Diabetes Mellitus, Type 1 - blood
/ Diabetes Mellitus, Type 1 - diagnosis
/ Diabetes Mellitus, Type 1 - drug therapy
/ Diabetes Mellitus, Type 1 - surgery
/ Endocrinology
/ Endocrinology General
/ Female
/ Follow-Up Studies
/ Genetics
/ Genetics General
/ Glucagon
/ Glucose
/ Glycated Hemoglobin - analysis
/ Hemoglobin
/ Humans
/ Hypoglycemia
/ Hypoglycemia - blood
/ Hypoglycemia - diagnosis
/ Hypoglycemia - etiology
/ Hypoglycemic Agents - therapeutic use
/ Immunosuppressive agents
/ Immunosuppressive Agents - administration & dosage
/ Infusions, Intravenous
/ Insulin
/ Insulin - therapeutic use
/ Islets of Langerhans - cytology
/ Islets of Langerhans Transplantation - adverse effects
/ Islets of Langerhans Transplantation - methods
/ Male
/ Meningitis
/ Middle Aged
/ Neutropenia
/ Pediatrics
/ Pediatrics General
/ Peptides
/ Portal vein
/ Recovery of function
/ Statistical analysis
/ Stem Cells
/ Transplantation, Homologous
/ Transplants & implants
/ Young Adult
2025
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Stem Cell–Derived, Fully Differentiated Islets for Type 1 Diabetes
by
Markmann, James F.
, Witkowski, Piotr
, Kandeel, Fouad
, Kean, Leslie S.
, Peters, Anne L.
, Reichman, Trevor W.
, Rickels, Michael R.
, Marigowda, Gautham
, de Koning, Eelco J.P.
, Wang, Chenkun
, Ricordi, Camillo
, Bruinsma, Bote G.
, Pagliuca, Felicia
, Mathieu, Chantal
, Mascia, Molly
, Odorico, Jon
, Fung, John J.
, Wijkstrom, Martin
, Sanna, Bastiano
, Melton, Doug
in
Adult
/ Blood Glucose - analysis
/ C-Peptide - blood
/ Cell Differentiation
/ Cell therapy
/ Childhood Diseases
/ Cognition
/ Dementia disorders
/ Diabetes
/ Diabetes mellitus (insulin dependent)
/ Diabetes Mellitus, Type 1 - blood
/ Diabetes Mellitus, Type 1 - diagnosis
/ Diabetes Mellitus, Type 1 - drug therapy
/ Diabetes Mellitus, Type 1 - surgery
/ Endocrinology
/ Endocrinology General
/ Female
/ Follow-Up Studies
/ Genetics
/ Genetics General
/ Glucagon
/ Glucose
/ Glycated Hemoglobin - analysis
/ Hemoglobin
/ Humans
/ Hypoglycemia
/ Hypoglycemia - blood
/ Hypoglycemia - diagnosis
/ Hypoglycemia - etiology
/ Hypoglycemic Agents - therapeutic use
/ Immunosuppressive agents
/ Immunosuppressive Agents - administration & dosage
/ Infusions, Intravenous
/ Insulin
/ Insulin - therapeutic use
/ Islets of Langerhans - cytology
/ Islets of Langerhans Transplantation - adverse effects
/ Islets of Langerhans Transplantation - methods
/ Male
/ Meningitis
/ Middle Aged
/ Neutropenia
/ Pediatrics
/ Pediatrics General
/ Peptides
/ Portal vein
/ Recovery of function
/ Statistical analysis
/ Stem Cells
/ Transplantation, Homologous
/ Transplants & implants
/ Young Adult
2025
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Stem Cell–Derived, Fully Differentiated Islets for Type 1 Diabetes
Journal Article
Stem Cell–Derived, Fully Differentiated Islets for Type 1 Diabetes
2025
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Overview
Zimislecel is an allogeneic stem cell–derived islet-cell therapy. This phase 1–2 study supports the hypothesis that zimislecel can restore physiologic islet function and thus treat persons with type 1 diabetes.
Publisher
Massachusetts Medical Society
Subject
/ Diabetes
/ Diabetes mellitus (insulin dependent)
/ Diabetes Mellitus, Type 1 - blood
/ Diabetes Mellitus, Type 1 - diagnosis
/ Diabetes Mellitus, Type 1 - drug therapy
/ Diabetes Mellitus, Type 1 - surgery
/ Female
/ Genetics
/ Glucagon
/ Glucose
/ Glycated Hemoglobin - analysis
/ Humans
/ Hypoglycemic Agents - therapeutic use
/ Immunosuppressive Agents - administration & dosage
/ Insulin
/ Islets of Langerhans - cytology
/ Islets of Langerhans Transplantation - adverse effects
/ Islets of Langerhans Transplantation - methods
/ Male
/ Peptides
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