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MED18 interaction with distinct transcription factors regulates multiple plant functions
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Journal Article
MED18 interaction with distinct transcription factors regulates multiple plant functions
2014
Overview
Mediator is an evolutionarily conserved transcriptional regulatory complex. Mechanisms of Mediator function are poorly understood. Here we show that
Arabidopsis
MED18 is a multifunctional protein regulating plant immunity, flowering time and responses to hormones through interactions with distinct transcription factors. MED18 interacts with YIN YANG1 to suppress disease susceptibility genes glutaredoxins
GRX480
,
GRXS13
and thioredoxin
TRX-h5
. Consequently,
yy1
and
med18
mutants exhibit deregulated expression of these genes and enhanced susceptibility to fungal infection. In addition, MED18 interacts with ABA INSENSITIVE 4 and SUPPRESSOR OF FRIGIDA4 to regulate abscisic acid responses and flowering time, respectively. MED18 associates with the promoter, coding and terminator regions of target genes suggesting its function in transcription initiation, elongation and termination. Notably, RNA polymerase II occupancy and histone H3 lysine tri-methylation of target genes are affected in the
med18
mutant, reinforcing MED18 function in different mechanisms of transcriptional control. Overall, MED18 conveys distinct cues to engender transcription underpinning plant responses.
Arabidopsis
contains multiple mediator proteins that function as transcriptional activators. Here, the authors show that MED18 has roles in plant immunity, control of flowering time and response to hormones, suggesting that mediator proteins control multiple pathways.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 49/15
/ 82/80
/ 96
/ Arabidopsis Proteins - physiology
/ Gene Expression Regulation, Plant - physiology
/ Hormones
/ Humanities and Social Sciences
/ Mediator Complex - physiology
/ Membrane Transport Proteins - physiology
/ Mutants
/ Plant Growth Regulators - physiology
/ RNA Polymerase II - physiology
/ Science
/ Trans-Activators - physiology
