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Trial of SAGE-217 in Patients with Major Depressive Disorder
by
Riesenberg, Robert
, Sankoh, Abdul J
, Gunduz-Bruce, Handan
, Doherty, James J
, Rubinow, David R
, Kanes, Stephen J
, Rothschild, Anthony J
, Paul, Steven M
, Zorumski, Charles F
, Li, Haihong
, Kaul, Inder
, Lasser, Robert
, Silber, Christopher
, Jonas, Jeffrey
in
Administration, Oral
/ Adult
/ Allosteric properties
/ Allosteric Regulation
/ Anesthesia
/ Antidepressants
/ Antidepressive Agents - adverse effects
/ Antidepressive Agents - therapeutic use
/ Anxiety
/ Clinical trials
/ Depressive Disorder, Major - classification
/ Depressive Disorder, Major - drug therapy
/ Dizziness - chemically induced
/ Double-Blind Method
/ Female
/ GABA Modulators - adverse effects
/ GABA Modulators - therapeutic use
/ Headache
/ Humans
/ Hypotheses
/ Least-Squares Analysis
/ Male
/ Mental depression
/ Middle Aged
/ Nausea
/ Nausea - chemically induced
/ Neurotransmission
/ Patients
/ Pregnanes - adverse effects
/ Pregnanes - therapeutic use
/ Psychiatric Status Rating Scales
/ Psychotherapy
/ Pyrazoles - adverse effects
/ Pyrazoles - therapeutic use
/ Receptors, GABA-A - metabolism
2019
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Trial of SAGE-217 in Patients with Major Depressive Disorder
by
Riesenberg, Robert
, Sankoh, Abdul J
, Gunduz-Bruce, Handan
, Doherty, James J
, Rubinow, David R
, Kanes, Stephen J
, Rothschild, Anthony J
, Paul, Steven M
, Zorumski, Charles F
, Li, Haihong
, Kaul, Inder
, Lasser, Robert
, Silber, Christopher
, Jonas, Jeffrey
in
Administration, Oral
/ Adult
/ Allosteric properties
/ Allosteric Regulation
/ Anesthesia
/ Antidepressants
/ Antidepressive Agents - adverse effects
/ Antidepressive Agents - therapeutic use
/ Anxiety
/ Clinical trials
/ Depressive Disorder, Major - classification
/ Depressive Disorder, Major - drug therapy
/ Dizziness - chemically induced
/ Double-Blind Method
/ Female
/ GABA Modulators - adverse effects
/ GABA Modulators - therapeutic use
/ Headache
/ Humans
/ Hypotheses
/ Least-Squares Analysis
/ Male
/ Mental depression
/ Middle Aged
/ Nausea
/ Nausea - chemically induced
/ Neurotransmission
/ Patients
/ Pregnanes - adverse effects
/ Pregnanes - therapeutic use
/ Psychiatric Status Rating Scales
/ Psychotherapy
/ Pyrazoles - adverse effects
/ Pyrazoles - therapeutic use
/ Receptors, GABA-A - metabolism
2019
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Trial of SAGE-217 in Patients with Major Depressive Disorder
by
Riesenberg, Robert
, Sankoh, Abdul J
, Gunduz-Bruce, Handan
, Doherty, James J
, Rubinow, David R
, Kanes, Stephen J
, Rothschild, Anthony J
, Paul, Steven M
, Zorumski, Charles F
, Li, Haihong
, Kaul, Inder
, Lasser, Robert
, Silber, Christopher
, Jonas, Jeffrey
in
Administration, Oral
/ Adult
/ Allosteric properties
/ Allosteric Regulation
/ Anesthesia
/ Antidepressants
/ Antidepressive Agents - adverse effects
/ Antidepressive Agents - therapeutic use
/ Anxiety
/ Clinical trials
/ Depressive Disorder, Major - classification
/ Depressive Disorder, Major - drug therapy
/ Dizziness - chemically induced
/ Double-Blind Method
/ Female
/ GABA Modulators - adverse effects
/ GABA Modulators - therapeutic use
/ Headache
/ Humans
/ Hypotheses
/ Least-Squares Analysis
/ Male
/ Mental depression
/ Middle Aged
/ Nausea
/ Nausea - chemically induced
/ Neurotransmission
/ Patients
/ Pregnanes - adverse effects
/ Pregnanes - therapeutic use
/ Psychiatric Status Rating Scales
/ Psychotherapy
/ Pyrazoles - adverse effects
/ Pyrazoles - therapeutic use
/ Receptors, GABA-A - metabolism
2019
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Trial of SAGE-217 in Patients with Major Depressive Disorder
Journal Article
Trial of SAGE-217 in Patients with Major Depressive Disorder
2019
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Overview
Patients with major depression were treated with an oral γ-aminobutyric acid type A–receptor modulator for 14 days. At day 15, patients who received the drug had a greater reduction in depressive symptoms than patients who received placebo. Headache was the most common adverse event.
Publisher
Massachusetts Medical Society
Subject
/ Adult
/ Antidepressive Agents - adverse effects
/ Antidepressive Agents - therapeutic use
/ Anxiety
/ Depressive Disorder, Major - classification
/ Depressive Disorder, Major - drug therapy
/ Dizziness - chemically induced
/ Female
/ GABA Modulators - adverse effects
/ GABA Modulators - therapeutic use
/ Headache
/ Humans
/ Male
/ Nausea
/ Patients
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