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Mezigdomide plus Dexamethasone in Relapsed and Refractory Multiple Myeloma
by
Pourdehnad, Michael
, Maciag, Paulo
, Pawlyn, Charlotte
, Karanes, Chatchada
, Amatangelo, Michael
, Pierce, Daniel W.
, Arnao, Mario
, Trudel, Suzanne
, Casas-Avilés, Ignacio
, Katz, Jessica
, Martinez-Lopez, Joaquín
, Popat, Rakesh
, Rodríguez Otero, Paula
, Gong, Jing
, Ramasamy, Karthik
, Mateos, María-Victoria
, Vangsted, Annette J.
, Lonial, Sagar
, Li, Shaoyi
, Orlowski, Robert Z.
, Wong, Lilly
, Richardson, Paul G.
, Poon, Jennifer
, Oriol, Albert
, Spirli, Alessia
, Berdeja, Jesus G.
, Peluso, Teresa
, Kim, Kihyun
, Quach, Hang
, Lamba, Manisha
, Bahlis, Nizar J.
in
Administration, Oral
/ Adverse events
/ Antibodies
/ Antineoplastic Agents - administration & dosage
/ Antineoplastic Agents - adverse effects
/ Antineoplastic Agents - therapeutic use
/ Biomarkers
/ Bone marrow
/ Confidence intervals
/ Dexamethasone
/ Dexamethasone - administration & dosage
/ Dexamethasone - adverse effects
/ Dexamethasone - therapeutic use
/ Drug dosages
/ Hematology
/ Humans
/ Hypotheses
/ Immunotherapy
/ Lenalidomide - adverse effects
/ Leukemia
/ Lymphocytes B
/ Lymphoma
/ Medical prognosis
/ Multiple myeloma
/ Multiple Myeloma - drug therapy
/ Neutropenia
/ Neutropenia - chemically induced
/ Neutrophils
/ Oncology
/ Pharmacodynamics
/ Pharmacokinetics
/ Recurrence
/ Schedules
/ Targeted cancer therapy
/ Treatments in Oncology
/ Ubiquitin-protein ligase
/ Ubiquitin-Protein Ligases
2023
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Mezigdomide plus Dexamethasone in Relapsed and Refractory Multiple Myeloma
by
Pourdehnad, Michael
, Maciag, Paulo
, Pawlyn, Charlotte
, Karanes, Chatchada
, Amatangelo, Michael
, Pierce, Daniel W.
, Arnao, Mario
, Trudel, Suzanne
, Casas-Avilés, Ignacio
, Katz, Jessica
, Martinez-Lopez, Joaquín
, Popat, Rakesh
, Rodríguez Otero, Paula
, Gong, Jing
, Ramasamy, Karthik
, Mateos, María-Victoria
, Vangsted, Annette J.
, Lonial, Sagar
, Li, Shaoyi
, Orlowski, Robert Z.
, Wong, Lilly
, Richardson, Paul G.
, Poon, Jennifer
, Oriol, Albert
, Spirli, Alessia
, Berdeja, Jesus G.
, Peluso, Teresa
, Kim, Kihyun
, Quach, Hang
, Lamba, Manisha
, Bahlis, Nizar J.
in
Administration, Oral
/ Adverse events
/ Antibodies
/ Antineoplastic Agents - administration & dosage
/ Antineoplastic Agents - adverse effects
/ Antineoplastic Agents - therapeutic use
/ Biomarkers
/ Bone marrow
/ Confidence intervals
/ Dexamethasone
/ Dexamethasone - administration & dosage
/ Dexamethasone - adverse effects
/ Dexamethasone - therapeutic use
/ Drug dosages
/ Hematology
/ Humans
/ Hypotheses
/ Immunotherapy
/ Lenalidomide - adverse effects
/ Leukemia
/ Lymphocytes B
/ Lymphoma
/ Medical prognosis
/ Multiple myeloma
/ Multiple Myeloma - drug therapy
/ Neutropenia
/ Neutropenia - chemically induced
/ Neutrophils
/ Oncology
/ Pharmacodynamics
/ Pharmacokinetics
/ Recurrence
/ Schedules
/ Targeted cancer therapy
/ Treatments in Oncology
/ Ubiquitin-protein ligase
/ Ubiquitin-Protein Ligases
2023
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Mezigdomide plus Dexamethasone in Relapsed and Refractory Multiple Myeloma
by
Pourdehnad, Michael
, Maciag, Paulo
, Pawlyn, Charlotte
, Karanes, Chatchada
, Amatangelo, Michael
, Pierce, Daniel W.
, Arnao, Mario
, Trudel, Suzanne
, Casas-Avilés, Ignacio
, Katz, Jessica
, Martinez-Lopez, Joaquín
, Popat, Rakesh
, Rodríguez Otero, Paula
, Gong, Jing
, Ramasamy, Karthik
, Mateos, María-Victoria
, Vangsted, Annette J.
, Lonial, Sagar
, Li, Shaoyi
, Orlowski, Robert Z.
, Wong, Lilly
, Richardson, Paul G.
, Poon, Jennifer
, Oriol, Albert
, Spirli, Alessia
, Berdeja, Jesus G.
, Peluso, Teresa
, Kim, Kihyun
, Quach, Hang
, Lamba, Manisha
, Bahlis, Nizar J.
in
Administration, Oral
/ Adverse events
/ Antibodies
/ Antineoplastic Agents - administration & dosage
/ Antineoplastic Agents - adverse effects
/ Antineoplastic Agents - therapeutic use
/ Biomarkers
/ Bone marrow
/ Confidence intervals
/ Dexamethasone
/ Dexamethasone - administration & dosage
/ Dexamethasone - adverse effects
/ Dexamethasone - therapeutic use
/ Drug dosages
/ Hematology
/ Humans
/ Hypotheses
/ Immunotherapy
/ Lenalidomide - adverse effects
/ Leukemia
/ Lymphocytes B
/ Lymphoma
/ Medical prognosis
/ Multiple myeloma
/ Multiple Myeloma - drug therapy
/ Neutropenia
/ Neutropenia - chemically induced
/ Neutrophils
/ Oncology
/ Pharmacodynamics
/ Pharmacokinetics
/ Recurrence
/ Schedules
/ Targeted cancer therapy
/ Treatments in Oncology
/ Ubiquitin-protein ligase
/ Ubiquitin-Protein Ligases
2023
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Mezigdomide plus Dexamethasone in Relapsed and Refractory Multiple Myeloma
Journal Article
Mezigdomide plus Dexamethasone in Relapsed and Refractory Multiple Myeloma
2023
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Overview
Oral mezigdomide is a cereblon-modifying agent that results in degradation of transcription factors essential for myeloma cell survival. Given with dexamethasone, it induced responses in 40% of heavily pretreated patients.
Publisher
Massachusetts Medical Society
Subject
/ Antineoplastic Agents - administration & dosage
/ Antineoplastic Agents - adverse effects
/ Antineoplastic Agents - therapeutic use
/ Dexamethasone - administration & dosage
/ Dexamethasone - adverse effects
/ Dexamethasone - therapeutic use
/ Humans
/ Lenalidomide - adverse effects
/ Leukemia
/ Lymphoma
/ Multiple Myeloma - drug therapy
/ Neutropenia - chemically induced
/ Oncology
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