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T cells from patients with Parkinson’s disease recognize α-synuclein peptides
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T cells from patients with Parkinson’s disease recognize α-synuclein peptides
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Journal Article
T cells from patients with Parkinson’s disease recognize α-synuclein peptides
2017
Overview
Epitopes derived from two regions of α-synuclein elicit immune responses in patients with Parkinson’s disease, involving IL-5-secreting CD4
+
T cells, as well as IFNγ-secreting CD8
+
cytotoxic T cells.
A possible immune component to Parkinson's disease
Major pathological hallmarks of Parkinson's disease are the death of neurons in the substantia nigra, a region of the brain associated with movement, and the presence of intraneuronal aggregates of α-synuclein. Genetic studies associate Parkinson's disease with alleles of the major histocompatibility complex. David Sulzer and colleagues show here that a defined set of peptides derived from α-synuclein is able to elicit a specific immune response from T cells obtained from Parkinson's disease patients. This suggests that there may be an immune component to the origins of Parkinson's disease, involving CD4
+
T cells as well as CD8
+
cytotoxic T cells, which may explain the reported association of Parkinson's disease with alleles of the acquired immune system.
Genetic studies have shown the association of Parkinson’s disease with alleles of the major histocompatibility complex
1
,
2
,
3
. Here we show that a defined set of peptides that are derived from α-synuclein, a protein aggregated in Parkinson’s disease
4
, act as antigenic epitopes displayed by these alleles and drive helper and cytotoxic T cell responses in patients with Parkinson’s disease. These responses may explain the association of Parkinson’s disease with specific major histocompatibility complex alleles.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 13/51
/ 631/250
/ Aged
/ Alleles
/ alpha-Synuclein - immunology
/ Antigens
/ Dopamine
/ Epitopes
/ Epitopes, T-Lymphocyte - immunology
/ Female
/ Humanities and Social Sciences
/ Humans
/ letter
/ Major histocompatibility complex
/ Male
/ Parkinson Disease - genetics
/ Parkinson Disease - immunology
/ Parkinson Disease - pathology
/ Patients
/ Peptide Fragments - chemistry
/ Peptide Fragments - immunology
/ Peptides
/ Proteins
/ Science
/ T-Lymphocytes, Cytotoxic - immunology
/ T-Lymphocytes, Cytotoxic - pathology
