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Genome Sequencing in Myeloid Cancers
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Genome Sequencing in Myeloid Cancers
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Journal Article
Genome Sequencing in Myeloid Cancers
2021
Overview
To the Editor:
Duncavage et al. (March 11 issue)
1
describe the use of whole-genome sequencing as an alternative to cytogenetic analysis in myeloid cancers. We confirmed the investigators’ findings by performing whole-genome sequencing of 440 samples obtained from patients with acute myeloid leukemia (AML) with each base sequenced 100 times (i.e., 100× coverage), along with reviewing orthogonal data of targeted next-generation sequencing and cytogenetic analysis. However, the minimum coverage needed for tumor sequencing is still under debate. Thus, we performed a down-sampling experiment that included 466 small variants (variant allele frequency [VAF], 1 to 98%), as identified by targeted next-generation . . .
Publisher
Massachusetts Medical Society
