Asset Details
Do you wish to reserve the book?
Chlamydia trachomatis Persistence In Vitro: An Overview
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Chlamydia trachomatis Persistence In Vitro: An Overview
Do you wish to request the book?
Chlamydia trachomatis Persistence In Vitro: An Overview
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Chlamydia trachomatis Persistence In Vitro: An Overview
2010
Overview
Chlamydiae growing in target mucosal human epithelial cells in vitro can transition from their normal developmental cycle progression, alternating between infectious but metabolically inactive elementary bodies to metabolically active but noninfectious reticulate bodies (RBs) and back to elementary bodies, into a state of persistence. Persistence in vitro is defined as viable but noncultivable chlamydiae involvingmorphologically enlarged, aberrant, and nondividing RBs. The condition is reversible, yielding infectious elementary bodies after removal of the inducers, including penicillin, interferon-γ, iron or nutrient starvation, concomitant herpes infection, or maturation of the host cell into its physiologically differentiated state. All aberrant RB phenotypes are not the same, owing to differing up- or down-regulated chlamydial gene sets and subsequent host responses. Although all persistence-inducing conditions exist in vivo, key questions include (1) whether or not aberrant chlamydial RBs occur in vivo during the alternating acute-silent chronic-acute chlamydial infection scenario that exists in infected patients and animals and (2) whether such aberrant RBs can contribute to prolonged, chronic inflammation, fibrosis, and scarring.
Publisher
The University of Chicago Press,University of Chicago Press
Subject
Anti-Bacterial Agents - pharmacology
/ Chlamydia Infections - microbiology
/ Chlamydia trachomatis - cytology
/ Chlamydia trachomatis - drug effects
/ Chlamydia trachomatis - growth & development
/ Chlamydia trachomatis - pathogenicity
/ Chlamydia trachomatis - physiology
/ DURATION OF CHLAMYDIA TRACHOMATIS INFECTION: CLEARANCE AND PERSISTENCE
/ Epithelial Cells - microbiology
/ Female
/ Humans
/ L cells
