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A Fourier‐Transform Infrared Spectroscopy‐Based Simple, Rapid, and Direct Quantification Assay for Moxifloxacin
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A Fourier‐Transform Infrared Spectroscopy‐Based Simple, Rapid, and Direct Quantification Assay for Moxifloxacin
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Journal Article
A Fourier‐Transform Infrared Spectroscopy‐Based Simple, Rapid, and Direct Quantification Assay for Moxifloxacin
2025
Overview
In the present study, a partial least square regression (PLSR) was applied to Fourier‐transform infrared (FTIR) data for rapid and direct quantification of a quinolone family antibiotic moxifloxacin and the proposed method was counter validated by reverse‐phase high‐performance liquid chromatography under diode array detection (RP‐HPLC‐DAD). The PLSR‐based processing of FTIR spectra of moxifloxacin standards and formulations disclosed a concentration‐dependent mid‐IR region at 1456 cm −1 . The FTIR‐based assay method was validated in accordance with the International Conference on Harmonization (ICH) guidelines and was found to be linear over the concentration range of 0.1 mg/mg–1.0 mg/mg (w/w) of solid mixtures with a coefficient of determination ( R 2 ) of 0.9951. Moreover, the results when counter validated by RP‐HPLC‐DAD were found to be concordant (RSD ≤ 2%). The analysis of moxifloxacin quality control samples through the developed FTIR assay offered overall recovery rates equals to 97.61%–103.74%. The real‐time analysis of moxifloxacin formulations marketed in Pakistan authenticated the presence of active pharmaceutical ingredients (APIs) within the claimed ranges. We can eventually conclude that FTIR spectroscopy if coupled with a suitable data‐processing scheme can provide more expedient, rapid, and economical choice for the direct quantification of moxifloxacin API and its formulations.
Publisher
John Wiley & Sons, Inc,Wiley
Subject
