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1H NMR based urinary metabolites profiling dataset of canine mammary tumors

by Ha, Taewoong , Sur, Jung-Hyang , Lee, Songyeon , Nam, Hojung , Seung, Byung-Joon , Park, Hee-Myung , Cheong, Jae-Ho , Yang, In Seok , Lee, Jueun , Kim, Sangwoo , Hwang, Geum-Sook

in 631/114/2415 / 631/45/320 / 631/67/1347 / Animal models / Biomarkers / Breast cancer / Cancer research / Data Descriptor / Datasets / ErbB-2 protein / Humanities and Social Sciences / Magnetic resonance spectroscopy / Mammary gland / Metabolites / Metabolomics / multidisciplinary / NMR / Nuclear magnetic resonance / Science / Science (multidisciplinary) / Spectrum analysis / Tumors

2022

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1H NMR based urinary metabolites profiling dataset of canine mammary tumors

by Ha, Taewoong , Sur, Jung-Hyang , Lee, Songyeon , Nam, Hojung , Seung, Byung-Joon , Park, Hee-Myung , Cheong, Jae-Ho , Yang, In Seok , Lee, Jueun , Kim, Sangwoo , Hwang, Geum-Sook

2022

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1H NMR based urinary metabolites profiling dataset of canine mammary tumors

by Ha, Taewoong , Sur, Jung-Hyang , Lee, Songyeon , Nam, Hojung , Seung, Byung-Joon , Park, Hee-Myung , Cheong, Jae-Ho , Yang, In Seok , Lee, Jueun , Kim, Sangwoo , Hwang, Geum-Sook

2022

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Journal Article

1H NMR based urinary metabolites profiling dataset of canine mammary tumors

Ha, Taewoong,

Sur, Jung-Hyang,

Lee, Songyeon,

Nam, Hojung,

Seung, Byung-Joon,

Park, Hee-Myung,

Cheong, Jae-Ho,

Yang, In Seok,

Lee, Jueun,

Kim, Sangwoo,

Hwang, Geum-Sook

2022

Overview

The identification of efficient and sensitive biomarkers for non-invasive tests is one of the major challenges in cancer diagnosis. To address this challenge, metabolomics is widely applied for identifying biomarkers that detect abnormal changes in cancer patients. Canine mammary tumors exhibit physiological characteristics identical to those in human breast cancer and serve as a useful animal model to conduct breast cancer research. Here, we aimed to provide a reliable large-scale metabolite dataset collected from dogs with mammary tumors, using proton nuclear magnetic resonance spectroscopy. We identified 55 metabolites in urine samples from 20 benign, 87 malignant, and 49 healthy control subjects. This dataset provides details of mammary tumor-specific metabolites in dogs and insights into cancer-specific metabolic alterations that share similar molecular characteristics. Measurement(s) Metabolite Technology Type(s) 1H nuclear magnetic resonance spectroscopy Factor Type(s) Age • Breeds • Sex • ER status • HER2 status • Histological grade • Neutral status Sample Characteristic - Organism Canis lupus familiaris

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Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio

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