Asset Details

MbrlCatalogueTitleDetail

Do you wish to reserve the book?

Chronic Pulmonary Aspergillosis: Genomic Variant Analysis and Protein Dysfunction Susceptibility in a Brazilian Cohort

by Vieira, Lucas Liro , Costa, Andre Nathan , Magri, Marcello Mihailenko Chaves , Costa Siemann, Mariana Ribeiro , Oliveira, Yanca Gasparini , Mendes, Rafaela da Silva , Moura, Eder Alencar , Nascimento, Karina Marinho , Wolff, Beatriz Martins , de Oliveira, Vítor Falcão , Carvalho, Gleyson Francisco da Silva , Rolim, Lissandro de Sousa , Kulikowski, Leslie Domenici

in Accountants / Adult / Aged / Aspergillosis / Brazil - epidemiology / Chronic Disease / Classification / Cohort Studies / CX3CR1 protein / Cytokines / Ethylenediaminetetraacetic acid / Female / Fungal infections / Genetic Predisposition to Disease / Genomes / Genomic analysis / Genomics / Humans / Immune response / Immunity (Disease) / Immunocompetence / Immunogenetics / Immunology / Interleukin 4 receptors / Lung diseases / Male / Medical research / Medicine, Experimental / Middle Aged / Mortality / Mutation / Neutropenia / Pathogens / Patients / Pattern recognition / Polymorphism, Single Nucleotide / Protein interaction / Proteins / Pulmonary aspergillosis / Pulmonary Aspergillosis - genetics / Tuberculosis

2025

Yes Please

Hey, we have placed the reservation for you!

By the way, why not check out events that you can attend while you pick your title.

Oops! Something went wrong.

Looks like we were not able to place the reservation. Kindly try again later.

Are you sure you want to remove the book from the shelf?

Chronic Pulmonary Aspergillosis: Genomic Variant Analysis and Protein Dysfunction Susceptibility in a Brazilian Cohort

2025

Confirm

Do you wish to request the book?

Chronic Pulmonary Aspergillosis: Genomic Variant Analysis and Protein Dysfunction Susceptibility in a Brazilian Cohort

2025

Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy

How would you like to get it?

Submit

We have requested the book for you!

Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.

Oops! Something went wrong.

Looks like we were not able to place your request. Kindly try again later.

Journal Article

Chronic Pulmonary Aspergillosis: Genomic Variant Analysis and Protein Dysfunction Susceptibility in a Brazilian Cohort

Vieira, Lucas Liro,

Costa, Andre Nathan,

Magri, Marcello Mihailenko Chaves,

Costa Siemann, Mariana Ribeiro,

Oliveira, Yanca Gasparini,

Mendes, Rafaela da Silva,

Moura, Eder Alencar,

Nascimento, Karina Marinho,

Wolff, Beatriz Martins,

de Oliveira, Vítor Falcão,

Carvalho, Gleyson Francisco da Silva,

Rolim, Lissandro de Sousa,

Kulikowski, Leslie Domenici

2025

Overview

Background/Objectives: Chronic pulmonary aspergillosis (CPA) is a debilitating condition often affecting immunocompetent patients with underlying structural lung diseases, particularly pulmonary tuberculosis. This study investigates single nucleotide variants (SNVs) in immunogenetic-related genes among a Brazilian cohort with CPA. Methods: Twelve patients with confirmed CPA, based on ESCMID/ERS criteria, were sequenced using custom multigenic panel sequencing. Variants were annotated, classified using ACMG guidelines, and analyzed for potential impact on protein interactions and immune pathways. Results: A set of SNVs in CX3CR1, IL12B, IL4R, PTX3, CCR5, and IFNG genes were classified as variants of uncertain significance (VUS), but protein–protein interaction analysis suggests a potential role in immune evasion and dysfunction. Conclusions: This is the first study to apply a custom multigenic panel for CPA susceptibility in a Brazilian cohort, contributing to future functional and clinical studies in fungal immunogenetics.

Share this book

Add to My Shelf

Publisher

MDPI AG,MDPI

Subject

Accountants

/ Adult

/ Aged

/ Aspergillosis

/ Brazil - epidemiology

/ Chronic Disease

/ Classification