Asset Details
Do you wish to reserve the book?
Transferrin-functionalized nanoparticles lose their targeting capabilities when a biomolecule corona adsorbs on the surface
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Transferrin-functionalized nanoparticles lose their targeting capabilities when a biomolecule corona adsorbs on the surface
Do you wish to request the book?
Transferrin-functionalized nanoparticles lose their targeting capabilities when a biomolecule corona adsorbs on the surface
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Transferrin-functionalized nanoparticles lose their targeting capabilities when a biomolecule corona adsorbs on the surface
2013
Overview
Nanoparticles have been proposed as carriers for drugs, genes and therapies to treat various diseases
1
,
2
. Many strategies have been developed to target nanomaterials to specific or over-expressed receptors in diseased cells, and these typically involve functionalizing the surface of nanoparticles with proteins, antibodies or other biomolecules. Here, we show that the targeting ability of such functionalized nanoparticles may disappear when they are placed in a biological environment. Using transferrin-conjugated nanoparticles, we found that proteins in the media can shield transferrin from binding to both its targeted receptors on cells and soluble transferrin receptors. Although nanoparticles continue to enter cells, the targeting specificity of transferrin is lost. Our results suggest that when nanoparticles are placed in a complex biological environment, interaction with other proteins in the medium and the formation of a protein corona
3
,
4
can ‘screen’ the targeting molecules on the surface of nanoparticles and cause loss of specificity in targeting.
When placed in a complex biological environment, targeting molecules on the surface of nanoparticles are shielded by surrounding biomolecules and their ability to bind to the targeted receptors on cells is lost.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Animals
/ Epithelial Cells - drug effects
/ Humans
/ letter
/ Mice
/ Nanotechnology and Microengineering
/ Proteins
/ Receptors, Transferrin - chemistry
/ RNA, Small Interfering - genetics
/ RNA, Small Interfering - isolation & purification
/ RNA, Small Interfering - metabolism
