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Imaging of pH in vivo using hyperpolarized 13C-labelled zymonic acid
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Imaging of pH in vivo using hyperpolarized 13C-labelled zymonic acid
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Imaging of pH in vivo using hyperpolarized 13C-labelled zymonic acid
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Journal Article
Imaging of pH in vivo using hyperpolarized 13C-labelled zymonic acid
2017
Overview
Natural pH regulatory mechanisms can be overruled during several pathologies such as cancer, inflammation and ischaemia, leading to local pH changes in the human body. Here we demonstrate that
13
C-labelled zymonic acid (ZA) can be used as hyperpolarized magnetic resonance pH imaging sensor. ZA is synthesized from [1-
13
C]pyruvic acid and its
13
C resonance frequencies shift up to 3.0 p.p.m. per pH unit in the physiological pH range. The long lifetime of the hyperpolarized signal enhancement enables monitoring of pH, independent of concentration, temperature, ionic strength and protein concentration. We show
in vivo
pH maps within rat kidneys and subcutaneously inoculated tumours derived from a mammary adenocarcinoma cell line and characterize ZA as non-toxic compound predominantly present in the extracellular space. We suggest that ZA represents a reliable and non-invasive extracellular imaging sensor to localize and quantify pH, with the potential to improve understanding, diagnosis and therapy of diseases characterized by aberrant acid-base balance.
Local pH alterations can be manifestations of pathologies such as cancer, inflammation and ischaemia. Here Düwel
et al
. show hyperpolarized
13
C-labelled zymonic acid can be used as a non-invasive probe to map and measure pH
in vivo
, suggesting it as a candidate for clinical imaging and a diagnostic tool.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
