Asset Details
Do you wish to reserve the book?
Serum In Vivo and In Vitro Activity of Single Dose of Ertapenem in Surgical Obese Patients for Prevention of SSIs
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Serum In Vivo and In Vitro Activity of Single Dose of Ertapenem in Surgical Obese Patients for Prevention of SSIs
Do you wish to request the book?
Serum In Vivo and In Vitro Activity of Single Dose of Ertapenem in Surgical Obese Patients for Prevention of SSIs
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Serum In Vivo and In Vitro Activity of Single Dose of Ertapenem in Surgical Obese Patients for Prevention of SSIs
2013
Overview
Background
Despite progress made in the control of post-operative infections, the incidence of surgical site infections (SSIs) is still high. An improper perioperative antibiotic use can expose patients to the risk of resistant microorganisms, and, in surgical obese patients, the drug dosage and infusion time are critical points. The aim of our study was to evaluate the effectiveness of ertapenem in the prophylaxis of SSIs in obese patients undergoing general or bariatric surgery.
Methods
A total of 63 obese patients, candidates for several surgical interventions, were enrolled and divided into two groups. Patients received antibiotic prophylaxis before surgery: the case group received venous infusion of ertapenem; the control group received standard prophylaxis. Serum samples were tested for antimicrobial activity against Gram-positive and Gram-negative bacteria.
Results
After single-dose ertapenem in obese patients, we registered in vitro activity of sera against the growth of non-extended beta lactamase (ESBL)-producing
Escherichia coli
,
Proteus mirabilis
,
Citrobacter freundii
,
Enterobacter cloacae
, and non-ESBL-producing
Klebsiella pneumoniae
. Moreover, methicillin-sensitive
Staphylococcus aureus
and
Streptococcus viridans
were also inhibited. We found in vivo efficacy according to clinical monitoring: at the weekly and monthly follow-ups, one patient in the case group and six patients in the control group presented superficial incisional SSIs.
Conclusions
These preliminary results are suggestive of the efficacy of ertapenem in perioperative prophylaxis of SSIs in obese patients; however, they need to be confirmed by further investigations and more defined trials.
Publisher
Springer-Verlag,Springer Nature B.V
Subject
/ Adult
/ Aged
/ Anti-Bacterial Agents - administration & dosage
/ Bariatric Surgery - adverse effects
/ beta-Lactams - administration & dosage
/ Enterobacter cloacae - isolation & purification
/ Escherichia coli - isolation & purification
/ Female
/ Humans
/ Klebsiella pneumoniae - isolation & purification
/ Male
/ Medicine
/ Obesity
/ Obesity, Morbid - complications
/ Obesity, Morbid - epidemiology
/ Practice Guidelines as Topic
/ Proteus mirabilis - isolation & purification
/ Surgery
/ Surgical Wound Infection - drug therapy
/ Surgical Wound Infection - epidemiology
