Asset Details
Do you wish to reserve the book?
Freeze-Drying as a Tool for Preparing Porous Materials: From Proof of Concept to Recent Pharmaceutical Applications
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Freeze-Drying as a Tool for Preparing Porous Materials: From Proof of Concept to Recent Pharmaceutical Applications
Do you wish to request the book?
Freeze-Drying as a Tool for Preparing Porous Materials: From Proof of Concept to Recent Pharmaceutical Applications
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Freeze-Drying as a Tool for Preparing Porous Materials: From Proof of Concept to Recent Pharmaceutical Applications
2025
Overview
Freeze-drying (FD) is the most extensive drying technique in pharmaceutical and biopharmaceutical industries. It relies on three main steps: freezing, primary, and secondary drying, where the sample is frozen and then dried by ice sublimation. FD possesses several features, mainly its suitability for heat-sensitive materials and its ability to produce dry products with improved physicochemical characteristics. Although FD is a gentle drying process, it can cause numerous stresses that induce chemical and physical instabilities. Herein, the addition of suitable excipients along with optimizing the process parameters is critical in attaining lyophilizates with high-quality attributes. Besides, the freeze-drying method has been explored as a unique route to produce porous materials with different applications. This work aims to dismantle the basics of freeze-drying and its role in developing porous materials, mainly amorphous and co-amorphous solid-dispersions, orodispersible tablets and films, as well as porous dressings and 3D scaffolds for effective wound healing and tissue engineering, respectively. The challenges and limitations of lyophilization have also been addressed.
Highlights
Freeze drying is a propitious drying method, especially for thermolabile materials.
The freeze-drying technique can form products with high-porous features.
The successful lyophilization cycle depends on understanding both the formulation variables and the process parameters.
Recent studies have shown that lyophilization under controllable conditions can develop porous materials with different applications and high-quality attributes.
Graphical Abstract
Publisher
Springer International Publishing,Springer Nature B.V
