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Abnormal Expression Pattern of Notch Receptors, Ligands, and Downstream Effectors in the Dorsolateral Prefrontal Cortex and Amygdala of Suicidal Victims
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Abnormal Expression Pattern of Notch Receptors, Ligands, and Downstream Effectors in the Dorsolateral Prefrontal Cortex and Amygdala of Suicidal Victims
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Journal Article
Abnormal Expression Pattern of Notch Receptors, Ligands, and Downstream Effectors in the Dorsolateral Prefrontal Cortex and Amygdala of Suicidal Victims
2014
Overview
Recent studies have associated alterations of neuronal plasticity in specific brain areas with suicidal behavior. The
Notch
signaling pathway plays a relevant role in the control of stem cell maintenance, cell migration, and neuronal plasticity. In the present study, the gene expression of the four
Notch
receptors (
NOTCH1
–
4
), the five canonical ligands (
DLL1
,
DLL3
,
DLL4
,
JAGGED1
, and
JAGGED2
), the two non-canonical ligands (
DLK1
and
DLK2
), and the transcription factors (
HES1
,
HEY1
, and
HEY2
) were measured in the dorsolateral prefrontal cortex (DLPFC) and amygdala (AMY) of suicide victims (S;
n
= 13 males, with no clinical psychiatric history and non-treated with anxiolytic or antidepressant drugs) and their corresponding controls (C;
n
= 13 males) by real-time PCR. The results revealed a reduction of
NOTCH2
and
NOTCH1
,
NOTCH3
, and
NOTCH4
gene expression in the DLPFC and AMY of S compared with C, respectively.
DLL1
levels were increased in the DLPFC and decreased in the AMY, whereas
DLL4
,
JAGGED1
, and
JAGGED2
were significantly decreased in the regions analyzed.
DLK1
was reduced in the AMY, whereas no changes were observed in the DLPFC and in
DLK2
expression levels in any of the regions analyzed.
HES1
was significantly reduced in both brain regions from S, whereas there were no significant changes in
HEY1
and
HEY2
. This study provides evidence suggesting that the
Notch
signaling pathway could be a potential key target in the treatment of suicidal behaviors.
Publisher
Springer US,Springer Nature B.V
